More than 130 jobs for Dublin and Galway have been announced by five companies from North America and Europe.
The companies are in the areas of IT, cybersecurity, life sciences and financial services.
Software analytics company New Relic, which has its headquarters in San Francisco, is establishing headquarters in Dublin for Europe, the Middle East and Africa, creating 50 new jobs.
SEKO MedTec Solutions will create 30 jobs in Galway. The global logistics business from Pennsylvania will establish a European Control Centre in the city.
Atlanta-based NeoMed Inc, a leading manufacturer of devices that deliver nutrition to the gut, is set to open a European, Middle East and Africa headquarters in Dublin, creating 22 jobs.
Arkansas-based energy consulting business capSpire will create 20 new business consultancy and software development jobs by opening its first international office in Ireland.
Internet domain name registry business Starting Dot, which has its headquarters in Paris, is opening a Finance and Operations Centre in Dublin.
It will create ten jobs across a number of activities.
The investments are supported by the Department of Jobs, Enterprise and Innovation through IDA Ireland, which has set up a specific division to focus on attracting high-potential, high-growth companies at an early stage of development.
Minister for Jobs Richard Bruton said: "Targeting high-growth emerging companies is a key part of the Government's Action Plan for Jobs.
"The thinking behind this drive is that these companies will establish deep roots here from early in their growth and make a substantial impact on our economy.
"There is also of course the possibility that one of these companies will turn into a world-leading company of the future."