Hospital campaigners say they are not reassured by comments from the HSE and the Department of Health regarding the future of Our Lady's Hospital in Navan.
Dr Ruairi Hanley of the Save Navan Hospital Campaign said 110 family doctors from around the north east had now added their names to an open letter.
This letter to Minister for Health Dr James Reilly outlines their concerns about the HSE plans for the hospital.
The campaign believes the HSE is planning to remove services from the hospital and have warned that this would "represent a serious threat to the health and safety of our patients."
In their letter to the Minister, the campaign group say they will publicly resist any efforts to downgrade the Our Lady's Hospital.
Dr Hanley said the number of doctors signing the public letter showed how worried they all are about the plans for Navan.
He said they had not been reassured by the statement from the HSE regarding their plans.
In the statement, the HSE said that the Department of Health is developing a framework for the future of smaller hospitals and until that has been completed "there will be no significant service changes at Navan or Dundalk."
In the meantime, the HSE said they will continue to work on improving the Emergency Department and related services at Our Lady of Lourdes Hospital in Drogheda "to continuously assess its capacity and readiness to deal with the increase in attendances already being experienced and any potential future increases."
The HSE statement went on to say that a priority is to ensure the long-term viability of hospitals in the region by ensuring they deliver safe, effective and efficient services within budget.