The Rehab Group, which provides support services and job opportunity for disabled people, has announced that it plans to recruit 750 staff in its operations over the next three years.
Over 400 of these positions will be based in Ireland.
The Rehab Group currently employs over 3,500 people, with 2,500 based in Ireland and another 1,000 in the UK, Poland and the Netherlands.
The new posts will be in the areas of training, education, health and social care, IT, sales and marketing, management and administration.
Speaking on RTÉ’s News at One, Rehab Group Chief Executive Angela Kerins said recruitment is already under way for the jobs.
Ms Kerins said that the jobs are open to anybody, but said that people with disabilities are being particularly encouraged to apply.
Minister for Jobs Richard Bruton, who made the announcement in Dublin, said: "Rehab is an Irish organisation which had success in its original field and branched out to new sectors creating large-scale employment.”
Rehab is Ireland's biggest provider of jobs for disabled people and runs a number of businesses in each of the four countries in which it operates.
It is Ireland's largest processor of glass for recycling and operates a retail business and an international logistics business.