A large section of the main thoroughfare in the Phoenix Park is to be closed for up to three months from the beginning of October to allow for the reconstruction of the roadway.
Major traffic disruption is expected as almost the entire length of Chesterfield Avenue will be closed to traffic.
The road is used by over 20,000 vehicles a day.
It has not weathered well during the recent harsh winters and despite a temporary resurfacing measure earlier this year, it has a large number of cracks, bumps and potholes.
The Office of Public Works is to carry out a €3m reconstruction project on the road which will begin on 3 October.
However that will involve closing the road from the Gough Roundabout near the Parkgate Street entrance to the Mountjoy Roundabout beside the Castleknock Gate.
A one-way system will be put in place inside the park which will essentially turn it into a large roundabout.
The road closure is likely to cause major traffic disruption and inconvenience some park users.
The reconstruction project is due to last about 12 weeks and the road should be reopened by Christmas.
The full traffic management plan will be published in the coming days.
The Minister of State at with special responsibility for the Office of Public Works, Brian Hayes, has insisted that the road works are necessary.
"Chesterfield Avenue was never designed to take the volume and weight of traffic that it does and the condition of the road has been a cause of increasing concern,” Mr Hayes said.
“The extreme weather conditions experienced in recent years have exacerbated the situation. While the surface degradation was the most immediate and evident sign of the problems prevailing, surveys confirmed that the underlying cause was with the substructure of the road and, in order to address the problem properly, work to the substructure is required.
“Works to achieve the necessary substantive repair and reconstruction of the most damaged areas of the road have been tendered and the contract has just been placed."
