The provision of 24-hour Emergency Department services is to end this year at St Columcille's Hospital Loughlinstown in Dublin.
Plans are also in place to stop accepting acute surgical services at the 106-bed hospital by the end of the year.
The changes are part of Health Service Executive reforms due to take place, or already under way, at eight other small hospitals around the country.
The 24-hour emergency service at St Columcille's will be replaced with a daytime minor injury service, however the HSE has said no date has been set.
The Health Information and Quality Authority said it has been informed that the 24-hour emergency services will cease at St Columcille's this year.
Last year, the hospital dealt with over 21,000 Emergency Department cases.
After the change, many of these will have to go to St Vincent's University Hospital, which has to agree to the exact date of the changeover.
Local People Before Profit Alliance TD Richard Boyd Barrett said it was 'utterly unacceptable to shut down the service' at Loughlinstown.
'Once again it is the most vulnerable in our society who are being forced to take the pain for the reckless gambling of bankers and developers,' he said.
Meanwhile, there are plans to stop accepting patients with major or complex emergency conditions, as well as inpatient acute or planned surgery, as part of the reconfiguration of services at Roscommon County Hospital.
The changes follow the findings of recent HIQA reports into the safety of services at Mallow General and Ennis General Hospital.
HIQA told the HSE it had to examine hospitals where the volume of acutely ill patients being seen is too low, or staffing levels are such that care cannot be provided safely.
Minister for Health Dr James Reilly has promised to publish a cost-containment plan for the health services in the coming weeks.
While no hospitals will close, changes in services are expected as part of reforms that have already taken place in the midwest and northeast region and are under way in the south.
Along with St Columcille's the main hospitals affected are, Roscommon County (84 beds), Navan General (172 beds), Louth County (65 beds), Portlaoise General (202 beds), Ennis General (94 beds), St John's Hospital, Limerick (103 beds), Mallow General (76 beds) and Bantry Hospital (118 beds).
