Taoiseach Enda Kenny will hold meetings with key business leaders on Wall Street in New York today.
In a series of media interviews, Mr Kenny has reiterated that Ireland's corporate tax rate of 12.5% is not negotiable and that the country is very much open for business.
Mr Kenny said an increase in corporate tax 'would be a massive breach of trust, particularly with American foreign direct investment in this country'.
The Taoiseach told Reuters Insiders Television that it was agreed at a recent eurozone meeting in Brussels that countries within the bailout package could have a reduction of interest rates applied to them.
Mr Kenny said that once details were finalised for a bailout for Portugal, the Irish Government could negotiate 'an interest rate reduction which would be significant in Ireland's case'.
The Fine Gael leader also said the Coalition is committed to selling €2bn worth of State-owned assets.
Any sale will be decided on the basis of which deals could add most jobs to the Irish economy.
On the banks, Mr Kenny said if Anglo Irish Bank needs more help that bondholders should expect to contribute.
He said: 'If a requirement comes in for further capital injection into Anglo Irish Bank, the Government will treat that accordingly.
'We would look at the question of senior bondholders in a very different light than we did when we didn't decide to burn senior bondholders with either Allied Irish Bank or Bank of Ireland.'