477 jobs are to be lost with the closure of RR Donnelley Global Turnkey Solutions in Raheen Industrial Estate in Limerick.
The company made the announcement today and said the job losses will be on a phased basis over the next nine months.
The job losses had been widely expected following the announcement by Dell, the company's main client, that it was closing its Limerick operation.
The decision was a result of 'customer's shifts in strategic direction' as well as global economic conditions, the company said.
The company, whose global headquarters are in Chicago, provides print and related services to businesses around the world.