Medical devices firm Boston Scientific is to close its plant in Letterkenny, Co Donegal, in 2010.
The company said most manufacturing at the plant, which employs 120 people, would be switched to its Galway facility.
The US company said opportunities would be made available for workers at Letterkenny to voluntarily move to the Galway plant.
Boston Scientific employs 4,500 people in Ireland.
The firm said it was still 'strongly committed' to its operations here.
It said the closure of the Letterkenny plant followed a review of the company's operations in Ireland.
Fine Gael’s Donegal North East TD Joe McHugh said the news is a terrible blow for the workforce and will further devastate the
county’s employment base.
He said: 'The loss of so many jobs in a town the size of Letterkenny will take a large chunk of revenue out of circulation, with a negative knock-on effect for the service sector.'
