Democrat Hillary Clinton and Republican Mitt Romney are projected to win Nevada's presidential nominating contests tonight.
Major networks predicted the Nevada victory for the New York senator, giving the former first lady added momentum going into the multiple contests that lie ahead in the nominating race for the US presidential election in November.
Mr Romney's convincing victory in Nevada followed his breakthrough win in Michigan last week after a series of disappointing second-place finishes for the former Massachusetts governor.
Among Democrats in Nevada, polls had shown Barack Obama, an Illinois senator, and Mrs Clinton, wife of former President Bill Clinton, in a tight duel after splitting the first two of the state-by-state contests.
In South Carolina, Republicans John McCain and Mike Huckabee fought for the lead in a race focused on the economy, with Romney and Fred Thompson hoping to shove their way to the top in a state where Republicans have a history as kingmakers.