Prince Harry and Meghan Markle say they are "humbled" to have graced the cover of Time magazine's 100 most influential people.

Taking to the Archwell website to address the news, the couple issued a statement saying:

"Prince Harry and Meghan, The Duke and Duchess of Sussex, are not only humbled to be part of this year's TIME 100 through the words of friend and partner José Andres, but to also write in praise of Dr. Ngozi Okonjo-Iweala for the publication’s annual list of Most Influential People."

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Over the past number of years, the annual 100 list has become a highly publicized event, highlighting the influence of the world's pioneers, icons, titans, and leaders across various industries.

Editor-in-chief Edward Felsenthal says this year's list features "extraordinary leaders from around the world working to build a better future, from entertainers striving to make Hollywood more inclusive to activists fighting for sustainability and human rights".

Praising Meghan and Harry for catalysing "essential conversations" on topics from mental health to misinformation, Felsenthal says that the couple fit right alongside the "disrupters, fixers, doers, iconoclasts, problem?solvers" who have "leaped into the fray".

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Over the past year, the cover stars have made headlines around the globe for their bold moves; famously stepping down as senior royals for a life in America, working on a variety of charitable and mental health projects.

As well as signing deals with Netflix and Spotify, the two founded the Archewell Foundation which aims to "uplift and unite communities - local and global, online and offline - one act of compassion at a time".

Writing a tribute for the 100 issue, chef and humanitarian José Andrés praised the pair for their "boots on the ground" compassion and their willingness to "run towards the struggle".

"They give voice to the voiceless through media production," he wrote. "Hand in hand with nonprofit partners, they take risks to help communities in need—offering mental-health support to Black women and girls in the U.S., and feeding those affected by natural disasters in India and the Caribbean."

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Photographed by Pari Dukovic, the eye-catching portrait marks the first time that the couple has formally posed together for a magazine cover.

"It captures their powerful dynamic as equal partners," says Dilys Ng, who has photo-edited the TIME100 covers for the past four years.

To see the TIME100 piece in full, click here.