Caitlyn Jenner has said she fears being sent to a men's prison if she is charged with and found guilty of misdemeanour manslaughter due to her involvement in a fatal car crash in Malibu earlier this year.

It was revealed last month that Jenner, who underwent gender reassignment surgery in April, may have manslaughter charges brought against her as a result of the crash, and the reality TV star has now broken her silence in an interview with US TV show Today's Matt Lauer.

Jenner described the crash as a tragedy that she will never get over, adding that the "worst case scenario" would see her serving time in an all-male prison.

"That is the worst case scenario. I don't know. We'll see. The Men's County Jail. It is an enormous problem that they would put trans-women in Men's County Jail," Jenner said.

Speaking of the crash itself, she said: "I remember it happening. That's about it. A tragedy like this, you'll never get over it. You just learn to live with it the best you possibly can."

During the crash, a white Lexus being driven by 69-year-old Kim Howe was shoved by Jenner's sport-utility vehicle across a centre divider and into oncoming traffic, where it was struck head-on by a Hummer.

Howe was killed in the collision and Jessica Steindorff, who was driving a black Toyota Prius also rear-ended by Jenner, was injured. Jenner escaped serious injury in the crash and declined medical treatment, authorities said.

Jenner released a statement shortly after the crash which read: "My heartfelt and deepest sympathies go out to the family and loved ones, and to all of those who were involved or injured in this terrible accident. It is a devastating tragedy and I cannot pretend to imagine what this family is going through at this time. I am praying for them. I will continue to cooperate in every way possible."

Howe's stepchildren are suing Jenner over the crash.