Original cast member Patrick Dempsey has left Grey's Anatomy after 11 seasons.
In a statement, US network ABC said: "After 11 seasons on Grey's Anatomy, Patrick Dempsey is moving on to pursue other interests."
It continued: "Dr Derek Shepherd is an iconic character and we've been proud to be the home of 'McDreamy' and the 'Mer/Der' love story.
"The devotion of Grey's fans throughout the years has been a testament to the creative mind of Shonda Rhimes and Dempsey's talent. 'McDreamy' will be greatly missed and we wish Patrick the very best in his future endeavors."