Matt Smith has joined Natalie Dormer in the upcoming action thriller Patient Zero.

According to Deadline, the Doctor Who actor will appear alongside the Game of Thrones star in Stefan Ruzowitzky's film about a group of survivors who have managed to avoid a global pandemic of rabies.

The mutated form of rabies has resulted in the evolution of a new species driven by violence and with its own language.

A human survivor who has the ability to communicate with the species leads a hunt for patient zero to find a potential cure to the epidemic.

Mike Le has written the script for the film.

Smith most recently starred in Ryan Gosling's directorial debut Lost River.