Ben White has gone home from the World Cup due to personal reasons and is not expected to return to the England camp.
The 25-year-old defender was included in Gareth Southgate's 26-man squad for Qatar following an impressive start to the season with Arsenal.
White did not feature in England's first two Group B matches and missed Tuesday's 3-0 win against Wales through illness.
A Football Association statement on Wednesday evening read: "Ben White has left England's training base in Al Wakrah and returned home for personal reasons.
"The Arsenal defender is not expected to return to the squad for the remainder of the tournament.
"We ask that the player's privacy is respected at this moment in time."

Stephanie Frappart, Neuza Back and Karen Diaz will become the first all-female refereeing team for a men's World Cup match after they were named to take charge of the Costa Rica-Germany game in Group E on Thursday.
Frappart, the fourth official for the Poland-Mexico Group C clash last week, will be the main referee as she reaches another milestone after being the first female to officiate at a men's World Cup qualifier in March and Champions League match in 2020.
The 38-year-old Frenchwoman will be joined by Brazilian Neuza and Mexican Diaz as assistants.
Salima Mukansanga of Rwanda and Yamashita Yoshimi of Japan are also taking part at the tournament in Qatar.

Members of the LGBTQ community can go to the World Cup in Qatar but the West cannot "dictate" to Qataris what they should believe, Qatar's energy minister told Germany's Bild newspaper.
Qatar's relations with Germany have been choppy of late.
German Interior Minister Nancy Faeser sported the "OneLove" armband at the national team's match against Japan last week and has criticised Qatar's human rights, but this week Germany sealed a deal to import liquefied natural gas (LNG) from Qatar.
"If they want to visit Qatar, we have no problem with it," Minister of State for Energy Affairs Saad Sherida Al-Kaabi said of the lesbian, gay, bisexual and transgender community.
But he said the West wants to "dictate what it wants" to Qatar, where homosexuality is illegal.
"If you want to change me so that I will say that I believe in LGBTQ, that my family should be LGBTQ, that I accept LGBTQ in my country, that I change my laws and the Islamic laws in order to satisfy the West – then this is not acceptable," he added.

Spain manager Luis Enrique says his daily streaming sessions to Spain fans during the World Cup are part of efforts to keep a fun vibe in his team's camp, and he brushed off talk of having strict rules for his players in Qatar.
Luis Enrique took the unusual step of starting a daily Twitch livestream when his squad arrived for the World Cup to reach out directly to Spain fans. The sessions were an instant hit.
"My streaming sessions and posting, everyone can have their own reading or interpretation, I didn't start doing this with any specific goal," he told a news conference.
"There are so many cliches about training camps having to be very strict. I don't know who came up with this. Imagine how long the players are off. They have so much time off to be bored. Having to follow strict rules. That's ridiculous."
He said it was vital for players to be able to have a release from all the pressures that a World Cup brings.
"The only goal I set for my players...before this training camp 16 days ago, I told them we need to have fun, fun. We need to enjoy this because you have to joy in your job."
Spain play Japan in the final Group E match on Thursday, where a draw would secure Luis Enrique's team a last 16 spot, while a win would see them top the group after their 7-0 drubbing of Costa Rica and 1-1 draw with Germany.
Luis Enrique's streaming sessions have touched on all kinds of issues about the World Cup and life in the Spain camp, including, according to some media reports, light-hearted jokes about his players' sex lives.
He said it was important for his players to get days off too and see family
"They're football players. Some of them are young boys. They have family children, who have to act with normalcy
"Having a day off after 10 days of a training camp. It's not crazy. To go out for a walk with your wife, family members. That's a good sign.
"Yes, they're under so much pressure."

Belgium's Timothy Castagne said on Wednesday the team was not in crisis after two lacklustre performances in the World Cup group stage that has prompted introspection ahead of a must-win match against Croatia to reach the knockout stage.
Ranked second in the world, Belgium prevailed 1-0 over Canada but were vastly outplayed, and suffered an embarrassing 2-0 defeat to Morocco in their subsequent Group F match.
"The first two games were not as good as we hoped. We didn't show everything we are capable of," Castagne said. "But we are not in crisis."
Belgium will almost certainly have to beat Croatia on Thursday to advance to the last 16. A draw for Croatia will be enough to see them into the knockout, but Belgium will then be relying on Canada defeating Morocco by three goals to stand a chance to progress.
Belgian players have publicly admitted they were disappointed with their showing in Qatar and said that frank words had been exchanged amongst them at a team meeting following their loss to Morocco on Sunday.
The meeting sparked speculation of a rift on the team, which lost to eventual champions France in the semi-finals of the 2018 World Cup.
"It was important to get things off our chests and share our views," Castagne said. "We also shared our ideas about how we can improve."
Manager Roberto Martinez said pressure had gotten the best of his players after they finished third in 2018. He said they were now focused on enjoying their match and playing fearlessly against the 2018 runners-up.
"There was no enjoyment. There was too much responsibility," Martinez said of his team's first two matches. "Every player was fearful of losing. We are not expected to lose...Tomorrow there is no doubt. A draw and we are out."

Morocco coach Walid Regragui will not make the mistake of playing for a draw against Canada as they look to make it out of the World Cup group stage for the first time in more than 35 years.
Following a stunning 2-0 victory over Belgium, the Atlas Lions stand on the verge of reaching the knockout rounds for only the second time in the country's history, last doing so in 1986.
Canada, meanwhile, have only pride left to play for following a 4-1 defeat to Croatia after being edged out by Belgium in the opening Group F match after Alphonso Davies’ first-half penalty was saved.
Regragui, though, maintains Morocco must stay fully focussed against a team intent on finishing the tournament on a positive note as Canada look ahead to co-hosting the 2026 World Cup.
"We know that we are coming up against a team which has got nothing to lose as they are already eliminated and will be out to hold their heads up high," said Regragui, who replaced Vahid Halilhodzic as Morocco head coach just three months ago.
"But we also have a lot to get out of the game. We are motivated and are preparing for a difficult game."
Regragui added: "It would be an error to go into the match thinking you only need to give 20 or 30% because the draw is fine for us.
"We are coming up against a team who want to take their first points from a World Cup, so they will be giving it everything right up until the final whistle.
"But we are there to win as well – if we are looking for the draw, that would be a mistake."
Morocco goalkeeper Yassine Bounou is expected to be available again after being replaced shortly ahead of kick-off against Belgium as he was feeling dizzy.
Canada head coach John Herdman hopes his squad can produce a display which does credit to their progress after reaching the World Cup finals for the first time since 1986, when the team lost all three group games without scoring a goal.
"Tomorrow is a real opportunity for our players, for our country, to keep stepping forward. As a group we have tactically – and with our identity – taken some big steps in this tournament," the Englishman said.
"Football people have been waiting for Canada to arrive and were wondering how we were going to show up – I think we showed up on the front foot and that will be our approach again.
"We will stay committed to our identity and we will go into this match with an opportunity to make some more history."

Rumours of Belgium's demise are greatly exaggerated, Croatia's head coach Zlatko Dalic said as he prepares his side for Thursday's decisive Group F showdown.
Croatia, who beat Belgium in the 2018 semi-finals, need just a point to guarantee progress to the last 16 while FIFA second-ranked side Belgium almost certainly need to win.
A shock 2-0 defeat by Morocco on Sunday was followed by talk of rifts in the Belgium camp, with playmaker Kevin de Bruyne and defender Jan Vertonghen reportedly at loggerheads.
De Bruyne was also reported to have said that Belgium's so-called Golden Generation is now too old to win the World Cup, but Dalic was having none of it when asked on Wednesday.
"We are playing against the second-best football team in the world and they were number one," he told reporters.
"They are a great team and if we could choose we would not have selected this match to be the decisive one.
"We will not fool ourselves by their under-performance in the last two games."
Croatia drew with Tunisia in their opener but hit top form in a 4-1 defeat of Canada, leaving them in good shape going in to the clash at the Ahmad Bin Ali Stadium.
Dalic has ruled out any notion that Croatia would be happy to play for a draw.
"We will play as we did against Canada, high quality, high tempo. It's going to be a difficult game," he said.
"Belgium are a top team, they have De Bruyne and Hazard and we will not be fooled by media stories and some rumours. We are expecting the best of Belgium, a top-notch national team.
"They haven't become a bad football players overnight. I am not focussed on any other aspects, we are just focussed on their strength and quality."
Belgium have so far been without their powerhouse striker Romelu Lukaku but he is expected to be back on Thursday which could spell bad news for Croatia's defence.
"We are preparing for him to start and that changes the Belgium game," Dalic said. "He is great in the air and is a great attacker. But if we plan well we will have half our work done and the otther half will be on the pitch."
Lukaku's former Chelsea team mate Mateo Kovacic had some simple advice for his team mates on how to deal with Lukaku.
"I will leave that to the coach but I will say 'just don't fight him.'"