Super Bowl champions the Philadelphia Eagles pulled off a remarkable victory over the Los Angeles Rams in a last-play thriller in the NFL.
The Eagles looked set to suffer a first loss of the season, but Joshua Karty's potential game-winning field goal attempt for the Rams was blocked by Jordan Davis, who returned it for a touchdown.
Jalen Hurts threw for three touchdowns and ran for one more as Philadelphia fought back from 26-7 down to claim a 33-26 success.
The Minnesota Vikings and Pittsburgh Steelers both warmed up nicely for next Sunday's trip to Croke Park with wins in their respective NFL week three match-ups.
Veteran quarterback Carson Wentz, making his first start for the Vikings, led his team to a facile win over a Cincinnati Bengals team shorn of their star quarterback, Joe Burrow.
Jake Browning, lining up under centre in place of Burrow, made little headway against a tough Vikings defence.
In New England, Pittsburgh didn't have it all their own way, but Aaron Rodgers helped ensure his team headed for Dublin with an identical two-wins, one-loss record as next Sunday's opponents with a late fourth-quarter drive to edge the Steelers ahead of the Patriots for the victory.
The 21-14 result would prove to be Rodgers first ever win at New England's famed Foxboro Stadium.
One of the most surprising results saw the struggling Cleveland Browns stage a stunning comeback to beat the Green Bay Packers 13-10.
The Browns trailed 10-0 with less than four minutes left, but engineered a late salvo capped by Andre Szmyt kicking a 55-yard field goal.
Shelby Harris had blocked a field goal attempt from Packers kicker Brandon McManus with 27 seconds left and Joe Flacco set up the winning score.
A thriller saw the Tampa Bay Buccaneers recover for a 29-27 victory over the New York Jets.
The Buccaneers looked set for a comfortable win, leading 23-6 heading into the final quarter but Will McDonald blocked a field goal attempt from Chase McLaughlin and returned it for a touchdown as the Jets took a one-point advantage.
However, McLaughlin had the final say with a 36-yard field goal, leaving the Jets still winless.
The Carolina Panthers claimed their first victory in style with a 30-0 win against the Atlanta Falcons while the Washington Commanders were also dominant, beating the Las Vegas Raiders 41-24.
The Houston Texans and the Tennessee Titans are both still looking for their first wins after respectively going down 17-10 to the Jacksonville Jaguars and 41-20 to the Indianapolis Colts.
Elsewhere, the Kansas City Chiefs claimed their first win of the season with a 22-9 victory over the New York Giants.
Kansas City improved to 1-2 with help from Giants quarterback Russell Wilson's two thrown interceptions.
Los Angeles Chargers kicker Cameron Dicker converted on a 43-yard field goal attempt as time expired to complete a come-from-behind 23-20 win for his side over the Denver Broncos.
LA trailed by seven in the final three minutes, but quarterback Justin Herbert found the end zone when it mattered most – connecting with Keenan Allen on a 20-yard attempt to draw his side level.
The Chargers’ players then did their job on both sides of the ball to quickly force a three-and-out and set up for Dicker’s game-winning kick.
The New Orleans Saints fell to 0-3 on the season after being demolished 44-13 by the Seattle Seahawks, while the San Francisco 49ers kept their winning streak alive with a 16-15 victory over the Arizona Cardinals.
And Chicago quarterback Caleb Williams threw for four touchdowns to lead the Bears over the Dallas Cowboys 31-14.
