The Tampa Bay Buccaneers scored in the dying seconds to overcome the Houston Texans 20-19.
The Buccaneers found themselves against the wall late on when Nick Chubb broke through Tampa Bay's defence to find the end zone on a 25-yard run and put the Texans up by five points with just over two minutes remaining.
However, Tampa Bay quarterback Baker Mayfield was able to lead an 11-play, 80-yard drive downfield, which was capped off by a two-yard, game-clinching touchdown run for Rachaad White with just six seconds left on the clock.
Mayfield, who finished with 216 passing yards and two touchdowns as the Buccaneers improved to a 2-0 record to start the season, said afterwards: "In these two-minute, close games, we were not on the right side of things for the past couple years.
"It's good to see that we haven't even played close to our best ball in all three phases and we're still finding ways to win on the road. That's really important to not lose sight of that."
The Los Angeles Chargers also remain undefeated this season after defeating the Las Vegas Raiders 20-9.
Las Vegas proved to be their own worst enemy as quarterback Geno Smith gave up three interceptions without finding the end zone.
Chargers quarterback Justin Herbert tallied two touchdowns and 246 yards through the air in the 11-point win.
"The defense, guardians of victory today," Chargers coach Jim Harbaugh enthused in his postgame press conference. "They had our back, our front, our side. It was just a tremendous defensive performance."
