Aaron Rodgers' Green Bay Packers will take on the New York Giants as the NFL brings three games to London later this year.
The Packers become the 32nd and final team to play in the capital since it first hosted a regular-season game in 2007 and will take on the Giants at the Tottenham Hotspur Stadium on 9 October.
Spurs will be hosting games on back-to-back weekends, with the New Orleans Saints - who currently have Irish-born punter Dan Whelan on their roster - taking on the Minnesota Vikings on 2 October.
The Jacksonville Jaguars continue their long-standing residency in London when welcoming the Denver Broncos, and their new quarterback Russell Wilson, to Wembley Stadium on 30 October.
Having beaten the Miami Dolphins at Tottenham Hotspur Stadium last season, the Jags return to their home away from home as they play under the arch for the eighth time since 2013.
Shahid Khan, Jags owner and chairman of Sky Bet Championship winners Fulham, said: "We were the first NFL team committed to play multiple games at Wembley and will be playing a home game here each season for at least the next three.
"We have the largest social following of any NFL team in the UK, our Foundation continues to expand, and we intend to keep growing.
"I look forward to being back in London to watch Fulham and the Jaguars play, in what I think will be a hugely exciting year ahead for fans of both teams."
Elsewhere, Tom Brady’s Tampa Bay Buccaneers will take on the Seattle Seahawks as Germany hosts its first NFL regular-season game on 13 November at Bayern Munich’s Allianz Arena.
The final international game takes place on 21 November in Mexico City at the Estadio Azteca, where the Arizona Cardinals take on the San Francisco 49ers in an all-NFC West encounter.