Josh Allen led the Buffalo Bills to a 31-6 win against the injury-hit New Orleans, who suffered their fourth consecutive defeat in the NFL.
Allen passed for 260 yards which included four touchdowns and two interceptions, with the quarterback registering multiple turnovers for his third game in four.
Buffalo tight end Dawson Knox hauled in two touchdown passes to record a franchise-best seven scores in a season, while wide receiver Stefon Diggs caught seven passes for a touchdown and 74 yards.
The Saints, meanwhile, struggled to make an impression through three quarters as their ground game again suffered due to the absence of injured running back Alvin Kamara.
The hosts finally got on the scoreboard with Trevor Siemian's 11-yard toss to tight end Nick Vannett at the start of the final quarter.
RAIDERS WIN! RAIDERS WIN!
— NFL (@NFL) November 26, 2021
📺: #LVvsDAL on CBS
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Earlier on Thanksgiving Thursday, Daniel Carlson kicked a 29-yard field goal with 4:28 left in overtime and the Las Vegas Raiders ended a three-game losing streak with a 36-33 victory over the Dallas Cowboys on Thursday at Arlington, Texas.
Carlson booted five field goals and Derek Carr completed 24 of 39 passes for 373 yards and one touchdown as Las Vegas (6-5) nabbed the crucial win.
The Raiders' DeSean Jackson (102 receiving yards) caught a TD pass and Hunter Renfrow established career highs of eight receptions and 134 yards.
Dak Prescott completed 32 of 47 passes for 375 yards and two touchdowns for the Cowboys (7-4), who have lost three of their past four games. Dallas' Tony Pollard returned a kickoff 100 yards for a touchdown.
Carlson kicked a career-long 56-yard field goal to give the Raiders a 33-30 lead with 1:52 remaining in regulation before Greg Zuerlein booted a tying 45-yard field goal for Dallas with 19 seconds to play.
Visiting Chicago edged winless Detroit as Cairo Santos kicked a 28-yard field goal as time expired.
The Bears controlled the ball for the last 8:30,spanning 18 plays.
Chicago's Andy Dalton threw for 317 yards and a touchdown, completing 24 of 39 passes with one interception. Darnell Mooney caught five passes for 123 yards for the Bears (4-7), who snapped a five-game losing streak.
Jared Goff completed 21 of 25 passes for 171 yards and two touchdowns for the Lions (0-10-1). Goff missed Detroit's previous game with an oblique injury.
Josh Reynolds had three receptions for 70 yards, including a 39-yard score.
