Kyler Murray threw four touchdown passes as the visiting Arizona Cardinals remain the lone unbeaten team in the NFL by rolling past the Cleveland Browns, 37-14.

Kyler Murray completed 20 of 30 passes for 229 yards, and DeAndre Hopkins hauled in a pair of scores as the Cardinals (6-0) cruised despite the absence of head coach Kliff Kingsbury (Covid19 protocols).

Already injury-riddled, Cleveland (3-3), saw quarterback Baker Mayfield (shoulder), wide receiver Odell Beckham Jr. (shoulder) and running back Kareem Hunt (calf) sustain injuries. Hunt did not return after his injury early in the fourth quarter.

Mayfield finished 19 of 28 for 234 yards and two touchdowns, but had three turnovers. Donovan Peoples-Jones had four catches for 101 yards and two touchdowns.

The Dallas Cowboys dug deep to emerge 35-29 overtime victors over the New England Patriots and cement their position at the top of the NFC East with a 5-0 winning streak.

Aaron Rodgers threw for two touchdowns and also ran in one score himself as the Green Bay Packers made it 10 wins in 11 games against old rivals the Chicago Bears.

The Packers moved to 5-1 for the season and stretched their advantage over their opponents at the top of the NFC North with a 24-12 win, with Rodgers celebrating his running score by shouting "I still own you!" at the Bears fans.

The Bears are now level at 3-3 with the Minnesota Vikings, whose quarterback Kirk Cousins threw the winning touchdown to KJ Osborn in overtime as they got the better of the Carolina Panthers 34-28.

The Detroit Lions remain winless at the bottom of the NFC North following a 34-11 loss to the Cincinnati Bengals.

Patrick Mahomes threw two interceptions but responded with two touchdowns and over 400 all-purpose yards as the Kansas City Chiefs recovered from a half-time deficit to defeat Washington 31-13.

The Los Angeles Rams beat the New York Giants 38-11, scoring four touchdowns in the second quarter as receiver Cooper Kupp and running back Darrell Henderson finished the day with two apiece.

The Baltimore Ravens enhanced their Super Bowl contender credentials with a convincing 34-6 win over the previously impressive Los Angeles Chargers.

Latavius Murray, Devonta Freeman and Le'Veon Bell all ran in touchdowns for the dominant Ravens as Chargers quarterback Justin Herbert was limited to a single touchdown.

Baltimore top the AFC North with a 5-1 record but the Chargers slipped to 4-2 in the AFC West.

The Indianapolis Colts defeated the Houston Texans 31-3, the Las Vegas Raiders overcame the resignation of coach Jon Gruden with a 34-24 win over AFC West rivals Denver Broncos, and quarterback Baker Mayfield reinjured his non-throwing shoulder as his Cleveland Browns fell 37-14 to the visiting Arizona Cardinals.

The Jacksonville Jaguars ended the second-longest losing streak in NFL history as Matthew Wright's last-gasp field goal sealed a stunning 23-20 victory against the Miami Dolphins in Sunday’s all-Florida clash in London.

A week on from the Atlanta Falcons overcoming the New York Jets, the Tottenham Hotspur Stadium was again packed to the rafters as the NFL London Games double-header came to a thrilling conclusion.

Both teams needed a shot in the arm after poor starts to the season and the Jaguars grabbed their chance, ending their 20-game losing run by beating the Dolphins thanks to Wright’s field goal at the death.