The Baltimore Ravens got the better of 2020 Super Bowl winners and last season's runners-up Kansas City Chief in a 36-35 shootout in Sunday's late game.
Although the Ravens played short-handed with 16 players already on injured reserve, quarterback Lamar Jackson willed his first victory in four match-ups against Patrick Mahomes and the two-time defending AFC champion Chiefs.
Jackson overcame two first-quarter interceptions, including one for a pick-six, to pass for 239 yards, rush for 107 and account for three touchdowns, rallying Baltimore from an 11-point deficit.
Mahomes completed passes to nine receivers, passing for 343 yards and three touchdowns, but threw the first September interception of his career.
Travis Kelce caught seven balls for 109 yards. His 46-yard touchdown with 6:50 left in the third quarter provided a 35-24 lead but the Chiefs did not score again as Odafe Oweh recovered Clyde Edwards-Helaire's fumble with 1:20 remaining to seal the win.
Defending Super Bowl champions Tampa Bay Buccaneers routed Atlanta Falcons 48-25.
Tom Brady threw for 276 yards and five touchdowns, with the Bucs scoring more than 30 points in a victory for a record ninth successive time.
Greg Joseph missed a last-minute field goal as Minnesota Vikings slipped to a 34-33 loss to Arizona Cardinals while Tennessee Titans recovered a 14-point deficit to stun Seattle Seahawks 33-30.
Dallas Cowboys were without starting ends Demarcus Lawrence and Randy Gregory because of injury and Covid protocols but impressed defensively in a 20-17 victory over Los Angeles Chargers.
The Chargers, playing in front of fans at SoFI Stadium for the first time, had two touchdowns called back due to penalties before Greg Zuerlein's 56-yard field-goal got the Cowboys off the mark for the season.
In the earlier games, the Buffalo Bills claimed the first shutout of the new NFL season to clinch a 35-0 win over Miami Dolphins.
It continued the Bills' dominance over the Miami side with this a sixth consecutive victory over Dolphins, who lost quarterback Tua Tagovailoa early on to a rib injury.
Devin Singletary’s 46-yard touchdown got the scoring started before Josh Allen found Stefon Diggs which made it 14-0 at the interval.
Allen picked out Dawson Knox early into the third quarter to reach the milestone of 10,000 career passing yards and two late TDs by Zack Moss helped Bills bounce back in style from an opening loss against Pittsburgh Steelers.
Every touchdown from NFL RedZone in Week 2! ?? pic.twitter.com/jx7OWz0TN1— NFL (@NFL) September 20, 2021
Carolina Panthers are two from two and Christian McCaffrey was able to open his account for the campaign on his return from an injury-hit last season.
The running back missed the majority of Matt Rhule’s debut term due to ankle and shoulder problems respectively and while he exited their 26-7 victory over New Orleans Saints early, it was only down to "cramp issues" according to the Charlotte-based team.
San Francisco 49ers also boast a 100% record after a 17-11 success against Philadelphia Eagles.
Jauan Jennings’ first NFL catch gave him a TD and Jimmy Garoppolo went from creator to scorer to help the 2020 runners-up stay perfect.
A sensational 102-yard TD return from Jamal Agnew could not prevent Jacksonville Jaguars suffering another loss, this latest to Denver Broncos.
Teddy Bridgewater helped Tim Patrick and Noah Fant go over for Broncos to earn a 23-13 win and Las Vegas Raiders can also boast two out of two.
Not even a minor ankle injury could stop Derek Carr pulling the strings for Raiders, who followed up a narrow triumph over Baltimore Ravens with a nine-point victory over Pittsburgh Steelers.
Matt Gay’s 38-yard field goal gave Los Angeles Rams a hard-fought win over Indianapolis Colts despite Kenny Young being ejected.
Young was forced to leave at the end of the third quarter after he appeared to make contact with the referee but Rams edged ahead late on through Cooper Kupp’s TD after Colts lost quarterback Carson Wentz to an ankle injury.
Six-time Super Bowl champions New England Patriots inflicted another loss on New York Jets with Nick Folk’s 13-point tally contributing towards a 25-6 win.
Elsewhere, Demetric Felton spun his way to a first NFL TD from 33 yards in Cleveland Browns 31-21 victory against Houston Texans while a knee injury forced off Chicago Bears quarterback Andy Dalton but they edged out Cincinnati Bengals by a 20-17 score.
A last-gasp 43-yard field goal gave Washington a 30-29 victory over New York Giants.