The New Orleans Saints became the first NFC team to secure a play-off spot after defeating the Atlanta Falcons 21-16 on Sunday.
The victory was the Saints' ninth consecutive win as Taysom Hill filled in successfully again for Drew Brees, throwing his first two NFL touchdown passes as a starting quarterback inside the first half.
Hill had made his first career start on 22 November and has continued to impress since Brees' injury.
The New York Jets almost brought their 344-day winless run to an end only to fall at the final hurdle against the Las Vegas Raiders.
Derek Carr threw a 46-yard touchdown pass to rookie Henry Ruggs in the final seconds of the fourth quarter as the Raiders won 31-28.
The Jets' defeat keeps them in line for the number one draft pick in next season's draft at 0-12.
Five players were ejected as the Miami Dolphins beat the Cincinnati Bengals 19-7 after two incidents prompted confrontation.
The Bengals led 7-6 at half time after their wide receiver Tyler Boyd and opposing cornerback Xavien Howard were ejected for a sideline scuffle.
The Dolphins hit back, eventually going on to win the game despite losing receivers DeVante Parker and Mack Hollins in an incident that saw Bengals safety Shawn Williams also dismissed.
The Minnesota Vikings clinched a narrow victory over the Jacksonville Jaguars in overtime.
The Jaguars took an early 9-0 lead as they searched for their first victory since the opening weekend of the season but the Vikings came back behind 120 yards rushing for Dalvin Cook and 121 receiving from Justin Jefferson.
James Robinson's touchdown forced overtime but after both teams missed late field goals, the Vikings' Dan Bailey was successful in overtime after Harrison Smith's interception.
The Cleveland Browns overcame the Tennessee Titans in an entertaining 41-35 win with Baker Mayfield throwing for a season-high 334 yards.
Mayfield's four touchdown passes came in the first half, with the Browns taking a 31-point lead before just holding on to win their fourth straight game.
The Detroit Lions beat Chicago Bears 34-30 in interim coach Darrell Bevell's first game since taking over from the sacked Matt Patricia.
Matthew Stafford threw for 402 yards and three touchdowns for the Lions, who bounced back from a Thanksgiving Day defeat to the Houston Texans.
Detroit were behind 30-20 early in the final quarter before they turned the game around with touchdowns from Marvin Jones and Adrian Peterson, aided by a Mitchell Trubisky fumble as the Bears fell to their sixth straight defeat.
The Indianapolis Colts secured a narrow 26-20 win over the Houston Texans.
Philip Rivers threw two touchdown passes as the Texans missed a late chance to seal victory when quarterback Deshaun Watson, who had previously been sacked for a safety to give up the only points of the second half, fumbled a bad snap in the red zone.
The resurgent New York Giants validated their position on top of the NFC East by surprising the Seattle Seahawks 17-12 courtesy of a strong defensive effort that caused quarterback Russell Wilson to constantly second-guess himself.
The Philadelphia Eagles fell 30-16 to the Green Bay Packers, whose signal-caller Aaron Rodgers became the fastest player to reach 400 career touchdown when he connected with Davante Adams in the third quarter.
The New England Patriots humbled the Los Angeles Chargers 45-0, while the Arizona Cardinals suffered their fourth loss in five games as the Los Angeles Rams capitalised on two fourth-quarter turnovers to emerge 38-28 victors in Phoenix.
And safety Tyrann Mathieu sealed a 22-16 win for the Kansas City Chiefs with his second interception of the game as he picked off the pass of Denver Broncos quarterback Drew Lock with 29 seconds left on the clock as the reigning Super Bowl champions claimed the first play-off spot in the AFC.