Drew Brees set NFL records for touchdown passes in a career and completion percentage in a game as the host New Orleans Saints defeated the Indianapolis Colts 34-7 on Monday night.

Brees, who entered the game one touchdown pass behind New England's Tom Brady and two behind former Colts and Denver Broncos quarterback Peyton Manning, threw four scoring passes. He broke Manning's record of 539 on a 5-yard pass to tight end Josh Hill on the first possession of the third quarter.

He appeared to have broken the record just before halftime, but his 5-yardpass to Tre'Quan Smith was negated by a pass interference penalty on Smith.

Brees, who surpassed Manning's record for career passing yards last season, completed 29 of 30 passes (96.7 percent) breaking the record of 96.6 percent(28 of 29) set by the Los Angeles Chargers' Philip Rivers against the Arizona Cardinals last season.

Brees passed for 307 yards and also threw touchdown passes to Michael Thomas, Smith and Taysom Hill. Thomas, the NFL's leader in receptions and receiving yards, had 12 catches for 128 yards.

Though it was Brees' night, the New Orleans defence made a statement a week after giving up 516 yards in a 48-46 loss to the San Francisco 49ers by holding Indianapolis to 205 yards and having a shutout until Jordan Wilkins ran 1 yard for a score with 3:56 left.

The NFC South champion Saints (11-3) stayed in contention for a first-round play-off bye.

The Colts, 6-8 after losing for the sixth time in seven games, were eliminated from playoff contention.

Brees drove the Saints to Wil Lutz's 33-yard field goal on their first possession, then threw a 15-yard scoring pass to Thomas for a 10-0 lead early in the second quarter.

After Brees' 21-yard scoring pass to Smith, Lutz kicked a 26-yard field goal as time expired to give New Orleans a 20-0 halftime lead.

After throwing the record-setter, Brees added a 28-yard touchdown to Taysom Hill to give the Saints a 34-0 lead after three quarters.

The Saints honoured the 10th anniversary of their 31-17 victory over the Colts in Super Bowl XLIV.