The New England Patriots halted a Green Bay Packers comeback to win 31-17.
Tom Brady completed 22-35 for 294 yards and a touchdown and Josh Gordon notched up 130 yards receiving as the Patriots improved to 7-2.
Aaron Rodgers had two touchdowns, his second tying the game at 17-17 in the third, but a one-yard rush from James White and Gordon 55-yard score sealed the win for New England.
Patrick Mahomes threw three touchdown passes - two to Travis Kelce - as AFC West leaders the Kansas City Chiefs beat the Cleveland Browns 37-21.
Mahomes continued the best start by an NFL quarterback in 68 years to inflict defeat on the Browns in their first game since the sacking of coach Hue Jackson.
In only his second season, Mahomes, who made just one start as a rookie, already has 29 touchdown passes and 3,185 yards, the most by any quarter-back from 10 games since 1950.
Kareem Hunt also found the end zone three times for the Chiefs on Sunday, two scoring runs and one receiving.
Ben Roethlisberger threw two touchdown passes and ran for a score to help the Pittsburgh Steelers overcome the Baltimore Ravens 23-16.
James Conner rushed for 107 yards to catch Roethlisberger's throw, with Antonio Brown claiming the other touchdown.
Steelers, top of AFC North, have now won four games in a row since falling to the Ravens at home in late September, while the Ravens scored only one touchdown in their third straight defeat.
Julio Jones ended his 12-game touchdown drought while Matt Ryan threw for 350 yards and four scores during the Atlanta Falcons' 38-14 defeat of the Washington Redskins.
Jones twisted away from Washington defender Ha Ha Clinton-Dix and into the end zone for his first touchdown catch since November last year.
The result was a third win in a row for the Falcons, while the Redskins, top of NFC, paid the price for some poor tackling.
Cam Newton completed 19 of 25 passes for two touchdowns during the Carolina Panthers' 42-28 win over the Tampa Bay Buccaneers.
Newton threw passes of 19 yards to Curtis Samuel and 17 yards to Greg Olsen.
Christian McCaffrey also scored twice for the Panthers as they recorded a 10th straight home win.
Rookie linebacker Jerome Baker scored the only touchdown to help the Miami Dolphins beat the New York Jets 13-6.
Baker intercepted Sam Darnold with 11 minutes left, while the Dolphins also defended resiliently,
Elsewhere, Jordan Howard scored two touchdowns as the Chicago Bears defeated the Buffalo Bills 41-9, and the Minnesota Vikings beat the Detroit Lions 24-9.
In the later games, the Los Angeles Rams' eight-game winning streak came to an end as Drew Brees led the New Orleans Saints to a 45-35 victory.
Russell Wilson had 235 yards passing, but the Los Angeles Chargers beat the Seattle Seahawks 25-17 and the Houston Texans edged out the Denver Broncos 19-17.
