Denver Broncos quarterback Peyton Manning passed Brett Favre to become the National Football League's all-time leader in passing yardage on Sunday although the Broncos lost 29-13.
Manning, who started Sunday's game versus the Kansas City Chiefs three yards shy of the all-time mark of 71,838 yards, broke the record after completing a four-yard pass to Ronnie Hillman in the first quarter.
After saluting the home crowd, the 39-year-old quarterback tossed the souvenir ball to the Denver sideline for safe keeping.
However, Manning then suffered the embarrassment of being benched for back-up Brock Osweiler at the end of the third quarter, having completed just five passes and thrown four interceptions.
It turned into a brutal night for the Manning brothers as Eli's New York Giants were beaten by a last-gasp 54-yard field goal which kept the New England Patriots unbeaten.
Stephen Gostkowski split the uprights from 54 yards with one second left as the Patriots rallied to beat the Giants 27-26 and move to 9-0.
Josh Brown's field goal restored New York's lead with 1:47 remaining, but Tom Brady drove the Patriots 44 yards downfield to set up his kicker.
A five-yard pass from Eli Manning to Odell Beckham Jr on New York's final drive was originally called a touchdown but then overturned on review as incomplete, and New York had to settle for a field goal which would ultimately cost them the game.
The Minnesota Vikings beat the Oakland Raiders 30-14 behind 203 yards and a touchdown from Adrian Peterson.
Cordarrelle Patterson returned a kick 97 yards for a score, and Peterson's 80-yard run to the house in the fourth quarter settled it.
That moves the Vikings to 7-2, top of the NFC North after the Detroit Lions beat the out-of-sorts Green Bay Packers to claim only their second win of the NFL season.
A generation of Lions fans witnessed something they'd never seen before on Sunday: A Lions victory at Lambeau Field.
Detroit (2-7) shocked the reeling Green Bay Packers (6-3) 18-16. The victory snapped the Lions' 24-game losing streak in Wisconsin, the longest in NFL history and one that dated to 1991 - before the Brett Favre-Aaron Rodgers era at quarterback. It was the first game for the Lions since general manager Martin Mayhew and president Tom Lewand were fired last week.
As is the Lions' way, it wasn't easy, as they survived a frantic Packers comeback but escaped when Green Bay kicker Mason Crosby appeared to mishit a 52-yard field-goal attempt on the final play.
In the late game, the Arizona Cardinals emerged from a wild fourth quarter with a 39-32 victory over the Seattle Seahawks which moved them three games clear in the NFC West.
The Cardinals had led 19-0 at one stage, 22-7 at half-time, but saw the Seahawks turn two turnovers into touchdowns early in the fourth quarter to snatch a 29-25 lead.
Carson Palmer responded with an 83-yard drive down field, capped by a 14-yard touchdown pass to Jermaine Gresham, and after Seattle had been held, Andre Ellington's 48-yard touchdown run with 1:58 left sealed the win.
Palmer finished with 363 yards and three touchdowns.
Kirk Cousins threw a career-high four touchdown passes and the Washington Redskins rolled up 513 yards of offense in a 47-14 rout of the New Orleans Saints.
Cousins completed 20 of 25 passes and threw for 324 yards, compiling a perfect passer rating of 158.3 against the NFL's 31st-ranked defence, while Washington running back Alfred Morris rushed for 93 yards, his most since Week One.
The game was tied at 14 in the second quarter before Washington (4-5) scored 33 straight points during a span that included safety Dashon Goldson's 35-yard interception for a touchdown on the third play of the fourth quarter to make 44-14.
Tight end Jordan Reed caught a pair of touchdown passes, and running back Matt Jones turned a screen pass into a 78-yard score for Washington, which has matched its victory total from last season.
Cam Newton completed 21 of 26 passes for 217 yards and one touchdown as the unbeaten Carolina Panthers (9-0) extended their best start ever with a 27-10 win over the Tennessee Titans at Nissan Stadium.
Newton also ran for a touchdown, marking the 30th game he has scored through the air and the ground. Only Steve Young has more with 31.
Carolina running back Jonathan Stewart led the Panthers in rushing with 91 yards and one touchdown on 22 carries.
The Titans (2-7) suffered their 10th consecutive home loss, their longest skid since moving to Tennessee.
The Tampa Bay Buccaneers got a one-yard bootleg touchdown run by quarterback Jameis Winston to defeat the Dallas Cowboys 10-6 at Raymond James Stadium, making up for a day filled with missed opportunities by their offense.
The winning score came one play after Winston fumbled the ball leaping over a defender on a touchdown attempt, but a Dallas holding call in the end zone bailed the Bucs out.
The next play, Winston executed the fake perfectly and strolled into the end zone for the only touchdown in the game over a Cowboys team that is mired in their first seven-game losing streak since 1989.
Dallas led at halftime on a pair of field goals but didn't score in the second half to drop to 2-7. Quarterback Tony Romo is expected to play next week for the first time since the team's last win in Week 2.
Ben Roethlisberger, who did not start because of a sprained left foot, entered the game early in the first quarter when starter Landry Jones was injured and led the Pittsburgh Steelers to a 30-9 victory over the Cleveland Browns at Heinz Field.
Roethlisberger was 22 for 33 for 379 yards and three touchdowns. He threw for 286 yards and two touchdowns in the first half alone.
Wide receiver Antonio Brown had 10 catches for 139 yards and two touchdowns and receiver Martavis Bryant had six catches for 178 yards and a touchdown.
Quarterback Johnny Manziel started a second consecutive game for the Browns because starter Josh McCown was inactive with a rib injury. He was 33 for 45 for 372 yards, but he did not lead the Browns to a touchdown until 12:28 remained in the game. He was also intercepted and lost a fumble.
Tight end Zach Miller and running back Jeremy Langford turned Jay Cutler throws into 87- and 83-yard touchdowns, respectively, in the first half as Chicago dumped the St Louis Rams 37-13 at Edward Jones Dome.
Miller's catch-and-run, the result of a failed tackle by linebacker Akeem Ayers, tied the game at 7 with 11:10 left in the first quarter. It answered a six-yard scoring run on the game's first possession by St. Louis' Todd Gurley.
Taking advantage of two nice blocks down field, Langford turned a screen pass into his long touchdown to give the Bears (4-5) a 24-10 lead with five minutes left in the first half.
On the strength of those two plays, Cutler hit 19-of-24 passes for 258 yards and three scores, finishing with a quarterback rating of 151.0.
The Miami Dolphins scored the game-winning points on a deflected pass in the fourth quarter as they overcame an early deficit to beat the Philadelphia Eagles 20-19 on Sunday at Lincoln Financial Field.
The Dolphins (4-5) took a 20-16 lead after a pass from quarterback Ryan Tannehill was batted high into the air at the line of scrimmage by Eagles linebacker Conner Barwin. The ball eventually landed in the arms of Miami receiver Jarvis Landry in the end zone with 14:55 left to play.
The Eagles (4-5) played the fourth quarter without starting quarterback Sam Bradford, who was knocked out of the game with a left shoulder injury late in the third quarter with the Eagles leading 16-13.
X-rays on Bradford's shoulder were negative, but he was also diagnosed with a concussion and sat out the rest of the game and was replaced by Mark Sanchez.
A face mask penalty by Baltimore Ravens linebacker Elvis Dumervil as time expired set up a 53-yard goal by Jason Myers that provided the Jacksonville Jaguars with an improbable 22-20 victory Sunday.
Dumervil was in the process of sacking Jaguars quarterback Blake Bortles on what would have been the final play of the game. But Dumervil grabbed Bortles' facemask and slung him to the ground. That penalty moved the line of scrimmage from the Ravens' 49-yard line to the 35 and gave the Jaguars one additional untimed play.
From there Myers booted the game-winning kick. Ravens safety Kendrick Lewis had let an easy interception slip through his hands on the final drive.
Jacksonville (3-6) snapped a 13-game losing streak on the road and improved to 3-6. The Ravens (2-7) lost for just the second time in eight games following a bye week under coach John Harbaugh.
