Tyrod Taylor threw for 277 yards and three touchdown passes as Buffalo Bills hammered Miami Dolphins 41-14 in Sunday night's NFL clash.
The result provided the perfect tonic for the Bills following last weekend's disappointing home loss to New England; the Dolphins dropped to last place in the AFC East on the back of their second straight defeat.
Seattle Seahawks also enjoyed a comfortable victory, thrashing the Chicago Bears 26-0 for their first win of the season.
The home team led only 6-0 at half-time, but Tyler Lockett took the opening second-half kick-off 105 yards - the longest in franchise history - for a touchdown and the Seahawks never looked back. Russell Wilson also found Jimmy Graham on a 30-yard TD.
Carson Palmer threw for 311 yards - stretching his NFL-best win streak to nine games - as Arizona Cardinals cruised to a 47-7 triumph over the San Francisco 49ers.
Larry Fitzgerald caught nine of 11 passes for 134 yards and two touchdowns for the Cardinals, who returned two of Colin Kaepernick's first four passes for TDs.
In the final game on Sunday night, Denver Broncos overcame Detroit Lions 24-12 at Ford Field.
Peyton Manning threw for 324 yards and two touchdowns as the Broncos improved to 3-0, while the Lions slipped to 0-3 - their worst start since 2010.
