Rafael Nadal is the latest player to withdraw from the US Open having called time on his 2021 season.
The 20-time grand slam champion, who won his fourth Flushing Meadows title in 2019, is still being troubled by the foot injury he suffered at the French Open which forced him to miss Wimbledon and the Olympics.
Spaniard Nadal, 35, wrote on Instagram: "Hello everyone, I wanted to inform you that unfortunately I have to end the 2021 season.
"Honestly, I have been suffering a lot more than I should with my foot for a year and I need to take some time."
Defending champion Dominic Thiem and five-time winner Roger Federer have also pulled out of this year's US Open.