Marat Safin will take on four-time champion Roger Federer in the last 32 after beating Pakistan's Aisam-Ul-Haq Qureshi in straight sets in the second round.
Spain's Tommy Robredo became the highest seed to fall so far, the 11th seed losing in straight sets to veteran Australian Wayne Arthurs.
But elsewhere there were victories for Ivan Ljubicic, Tommy Haas, James Blake, Dmitry Tursunov, Juan Carlos Ferrero, Jarkko Nieminen and Jonas Bjorkman.
Arthurs, 36, is scheduled to retire after Wimbledon but first faces Bjorkman in the third round, the veteran pair having a combined age of 71.
Former champion Lleyton Hewitt cruised into the last 32 with a straight sets win over Italian Simone Bolelli, the 16th seed winning 6-2 6-2 6-1.
Second seed Rafael Nadal enjoyed an easy passage into the third round with a straight sets victory over Austrian Werner Eschauer.
Nadal actually lost the first two games in the first set but roared back to take the next six in a row.
The French Open champion was in total command from then on, eventually winning 6-2 6-4 6-1.
Mens Singles Round Two:
(22) Guillermo Canas (Arg) bt Max Mirnyi (Blr) 6-7 (4-7) 6-1 7-6 (7-4) 7-6 (7-4), (15) Ivan Ljubicic (Cro) bt Jan Hernych (Cze) 6-4 6-3 6-4, (9) James Blake (USA) bt Andrei Pavel (Rom) 6-4 6-3 6-3, (7) Tomas Berdych (Cze) bt Michael Llodra (Fra) 7-6 (7-4) 7-6 (7-2) 3-6 7-6 (7-4), (10) Marcos Baghdatis (Cyp) bt Nicolas Devilder (Fra) 6-0 7-6 (7-5) 6-7 (4-7) 6-2, (4) Novak Djokovic (Ser) bt Amer Delic (USA) 6-3 3-6 6-3 7-6 (7-4), (21) Dmitry Tursunov (Rus) bt Michael Berrer (Ger) 4-6 6-4 6-4 6-4, (1) Roger Federer (Swi) bt Juan Martin Del Potro (Arg) 6-2 7-5 6-1, (20) Juan Carlos Ferrero (Spa) bt Gilles Muller (Lux) 6-4 6-4 6-7 (2-7) 7-6 (10-8), (28) Robin Soderling (Swe) bt Sebastien Grosjean (Fra) 6-3 3-6 6-3 6-2, (18) Jarkko Nieminen (Fin) bt Florian Mayer (Ger) 3-6 6-3 7-6 (7-2) 2-6 6-3, Paul-Henri Mathieu (Fra) bt (17) David Ferrer (Spa) 6-3 6-4 6-3, (23) David Nalbandian (Arg) bt Frank Dancevic (Can) 6-2 6-3 5-7 6-3, Jo-Wilfried Tsonga (Fra) bt Nicolas Lapentti (Ecu) 6-4 6-2 6-3, Gael Monfils (Fra) bt Kristof Vliegen (Bel) 7-5 7-6 (7-4) 7-6 (7-1), Hyung Taik Lee (Kor) bt (29) Agustin Calleri (Arg) 7-6 (8-6) 6-4 6-7 (3-7) 6-3, Wayne Arthurs (Aus) bt (11) Tommy Robredo (Spa) 6-3 7-6 (7-5) 6-3, (19) Jonas Bjorkman (Swe) bt Yeu-Tzuoo Wang (Tpe) 6-0 6-3 6-7 (8-10) 6-4, (16) Lleyton Hewitt (Aus) bt Simone Bolelli (Ita) 6-2 6-2 6-1, (14) Mikhail Youzhny (Rus) bt Gilles Simon (Fra) 6-4 4-6 3-6 7-5 6-4, Edouard Roger-Vasselin (Fra) bt (24) Juan Ignacio Chela (Arg) 7-6 (7-3) 6-4 7-5, (26) Marat Safin (Rus) bt Aisam-Ul-Haq Qureschi (Pak) 6-4 6-2 7-6 (7-4), (2) Rafael Nadal (Spa) bt Werner Eschauer (Aut) 6-2 6-4 6-1, (6) Nikolay Davydenko (Rus) bt Chris Guccione (Aus) 3-6 5-7 7-6 (7-5) 6-4 6-2, Feliciano Lopez (Spa) bt Tim Henman (Gbr) 7-6 (7-3) 7-6 (7-5) 3-6 2-6 6-1, Nicolas Kiefer (Ger) bt Fabrice Santoro (Fra) 6-4 6-3 6-4, (13) Tommy Haas (Ger) bt Tomas Zib (Cze) 6-3 7-6 (7-5) 6-4.
