Sky Bet League One strugglers Port Vale will travel to Chelsea in the quarter-finals of the FA Cup with Manchester City drawn at home to Liverpool.
After their shock win over Sunderland on Sunday, Vale, eight points adrift at the bottom of the table, are the lowest-ranked team left in the competition, making it through to the quarter-finals for the first time since 1954.
Chelsea twice came from behind to avoid another upset with a 4-2 extra-time victory over 10-man Wrexham a raucous Stok Cae Ras.
Premier League leaders Arsenal, having seen off Mansfield on Saturday, will head to Championship side Southampton, who won 1-0 at Fulham with an injury-time penalty from Ross Stewart.
Man City – 3-1 winners at Newcastle – will be at home against Arne Slot's side, who saw off Wolves in the fifth round on Friday night.
Leeds, who comfortably beat Norwich 3-0 on Sunday, will travel to West Ham.
The Irons edged past Brentford in a penalty shootout at the London Stadium on Monday night, the tie having finished 2-2 after extra-time.
The quarter-finals will be played around the weekend of 4 April.
