League One strugglers Port Vale are into the quarter-finals of the FA Cup for the first time in more than 70 years after boyhood Newcastle fan Ben Waine scored to stun Premier League Sunderland 1-0.
Five days after getting the goal that knocked out Bristol City, Waine - a New Zealand international whose mum's family hails from the north east of England - was at it again as his 28th-minute header gave Vale their first win over top-flight opposition since a fourth-round win over Everton 30 years ago.
Jon Brady's side sit rock bottom of the third tier, 11 points from safety in a 150th anniversary season that has offered little to celebrate so far, but this will go down as a famous day as they reached the last eight of the FA Cup for the first time since advancing to the semi-finals in 1954.
Waine's header was their only attempt on target in the 90 minutes but few inside Vale Park cared as the final whistle was greeted with huge celebrations.
Sunderland had made only two changes from the side that beat Leeds in midweek to move up to 11th in the Premier League, but a side featuring more than £150million (€173m) worth of talent blew the opportunity for the two-time FA Cup winners to reach the quarter-finals for the first time since 1974.
Southampton scored a stoppage-time penalty to defeat Fulham 1-0 at Craven Cottage to cause an FA Cup fifth-round upset.
An intriguing tie looked bound for extra-time until the 90th minute when Republic of Ireland international Finn Azaz smartly kept himself onside and was tripped by the trailing boot of Joachim Andersen inside the box.
From the spot, Ross Stewart hammered the ball hard and low into the corner beyond the fingertips of goalkeeper Benjamin Lecomte to ensure there will be a Championship team in Monday's quarter-final draw.
Fulham were without Harry Wilson, out with the ankle problem that forced him off during the home win against Tottenham, and in the absence of their best player there was a noticeable diminishing of creative output.
Nine changes made by Marco Silva from the midweek defeat to West Ham also seemed to contribute to a lack of fluency and bite in possession, with Southampton carrying arguably the greater threat until Silva sent on second-half reinforcements to try to tip the balance.
The Premier League side finally looked to be getting the better of Saints when, as the clock ticked over into the 90th minute, a moment of carelessness from Andersen handed Stewart the chance to spark delirious scenes in the away end.
Leeds United cruised into the FA Cup quarter-finals for the first time in 23 years with a 3-0 win at Elland Road against head coach Daniel Farke's former club Norwich City.
Sean Longstaff and Gabriel Gudmundsson struck first-half goals and Joel Piroe put the tie to bed in the closing stages as Leeds sealed a place in the last eight for the first time since 2003 under former manager Terry Venables.
Leeds bounced back to winning ways after successive Premier League defeats left them three points above the relegation zone, while Norwich failed to reproduce the form that saw them win nine of their previous 11 matches in all competitions.
Farke, who twice led Norwich to Premier League promotion and reached the FA Cup's last eight with them six years ago, watched from the stands as he served a one-game ban for his red card in last week's home defeat by Manchester City.