Bodo/Glimt added Inter Milan to their list of elite scalps this season with a 3-1 victory putting them within touching distance of the last 16 of the Champions League.
The Norwegian side had already beaten Manchester City and Atletico Madrid and the runaway Serie A leaders suffered the same fate as Jens Petter Hauge and Kasper Hogh struck in four second-half minutes after Francesco Esposito had cancelled out Sondre Brunstad Fet's opener for the hosts.
Bayer Leverkusen also have one foot in the next round after striker Patrik Schick scored twice in the second half as they beat Olympiacos away from home in their play-off round first leg.
The Czech striker, who is in form ahead of next month's World Cup qualification playoff against Republic of Ireland in Prague, scored twice in the space of four minutes around the hour mark to put the 2001/02 finalists in command in the tie.
But Atletico Madrid were left to rue squandering a two-goal lead in nine second-half minutes before conceding an 89th-minute equaliser to Christos Tzolis to draw 3-3 at Club Brugge.
Diego Simeone’s side have now shipped 15 goals in seven Champions League matches after Raphael Onyedika and Nicolo Tresoldi levelled up the tie on the hour after Julian Alvarez’s penalty, his 12th goal in 18 Champions League games, and Ademola Lookman had given them a comfortable lead.
Joel Ordonez’s own goal looked to have handed Atletico a lifeline but their lead lasted only 10 minutes.