Macclesfield must upstage another Premier League side if they are to continue their fairytale FA Cup run after drawing Keith Andrews' Brentford in the fourth round.
The National League North team produced one of the greatest upsets in the competition's history when they defeated holders Crystal Palace 2-1 at Moss Rose on Saturday.
John Rooney's charges are at home once again for their tie against Brentford, who are fifth in the Premier League.
"We said before that we would have liked to get Liverpool, Chelsea or Arsenal, but another Premier League side is incredible," Rooney said.
Elsewhere in the competition, Arsenal will entertain Wigan at the Emirates and Salford City or Swindon will travel to the Etihad to take on Manchester City.
Aston Villa will welcome Newcastle to the English midlands in an all-Premier League affair.
The fixtures will take place over the weekend of 14-15 February.
FA Cup fourth-round draw:
Liverpool v Brighton
Stoke City v Fulham
Oxford United v Sunderland
Southampton v Leicester City
Wrexham v Ipswich Town
Arsenal v Wigan
Hull City v Chelsea
Burton Albion v West Ham
Burnley v Mansfield Town
Norwich City v West Brom
Port Vale v Bristol City
Grimsby Town v Wolves
Aston Villa v Newcastle
Manchester City v Salford/Swindon
Macclesfield v Brentford
Birmingham City v Leeds
