Evan Ferguson failed to find the target as Roma fell to a 1-0 defeat to Atalanta in Serie A.
Giorgio Scalvini's bundled early goal was enough for Atalanta, who climb to eighth spot with Roma missing out on the chance to move into the top four.
Ferguson was replaced by Artem Dovbyk on the hour mark but Gian Piero Gasperini's side were unable to find a breakthrough.
Juventus were left frustrated after strugglers Lecce battled to a 1-1 draw at Allianz Stadium.
Lameck Banda put the visitors in front against the run of the play just before half-time.
Although Weston McKennie had Luciano Spalletti’s side level soon after the restart, Jonathan David then saw his Panenka penalty saved as Juve had to settle for just a point, which leaves them fourth.
Barcelona scored twice in the last five minutes to see off derby rivals Espanyol 2-0 at the RCDE Stadium and move seven points clear at the top of LaLiga.
Hansi Flick’s men looked to have been frustrated as they aimed to extend a winning run of eight league games against an Espanyol side who had recorded five straight victories themselves.
Substitute Dani Olmo, though, finally broke the deadlock with a cool finish and then Robert Lewandowski, having also come off the bench, wrapped things up in the 90th minute to leave Barca further clear of Real Madrid, who host Real Betis on Sunday.
Villarreal sit third after a 3-1 win at Elche, taking control with early goals from Alberto Moleiro and Georges Mikautadze before Alfonso Pedraza made sure late on.
In Ligue 1, Lille saw their winning run end in a 2-0 home defeat by Rennes, with defender Alexsandro Ribeiro having been sent off after only 13 minutes at Stade Pierre-Mauroy.
Przemyslaw Frankowski and Quentin Merlin scored for the visitors either side of the break, as Rennes consolidated sixth place.
Lyon kept up their own top-four ambitions with a 3-1 win at Monaco, who finished with 10 men after Mamadou Coulibaly was sent off with 20 minutes left – the midfielder having earlier equalised ahead of the break.
Strasbourg boss Liam Rosenior – heavily linked with the Chelsea job – saw his side pegged back as Nice came from behind to draw 1-1 at the Allianz Riviera, leaving the hosts without a win in five league games.
