Republic of Ireland goalkeeper Caoimhin Kelleher saved a penalty as Keith Andrews' Brentford piled more misery on Wolves with a 2-0 triumph at Molineux.
Wolves equalled the lowest Christmas points tally in Premier League history after falling to a 10th straight loss as Keane Lewis-Potter's brace secured victory for the Bees.
Rob Edwards' side were unable to match the performance that saw them go so close to a point at leaders Arsenal last weekend as their humiliating, winless start to the campaign continued.
Poor play allowed Lewis-Potter to score twice and settled a scrappy, forgettable encounter, which left rock-bottom Wolves with just two points from 17 matches heading into Christmas.
It is the same paltry tally that Sheffield United managed at this stage in 2020/21, albeit they had only played 14 matches.
Wolves supporters let their anger known, chanting "you're not fit to wear the shirt" on an afternoon that ended with Jorgen Strand-Larsen seeing a late penalty saved by Kelleher and loud, angry boos.
Super-sub Armando Broja scored a last-minute equaliser to end Burnley's seven-game losing run and leave Bournemouth winless in eight after a 1-1 draw.
Bournemouth thought they had won it when the sought-after Antoine Semenyo scored his eighth goal of the season to finally break through Burnley's spirited defence after 67 minutes.
But second-half substitutes Marcus Edwards and Broja combined to earn the returning Scott Parker a point his team had scarcely deserved.
Sunderland's impressive season following promotion to the top tier continued with a battling goalless draw at Brighton and Hove Albion.
Black Cats defender Omar Alderete went closest to a winner at the Amex Stadium when his 46th-minute header was pushed on to the crossbar by Seagulls goalkeeper Bart Verbruggen.
Yasin Ayari wasted the best of Brighton's opportunities as their winless run stretched to four matches, prompting a smattering of boos at full-time.
Sunderland, who have taken 27 points from 17 games, remain three points above the Seagulls ahead of ending a memorable 2025 at home to Leeds next weekend.
Dominic Calvert-Lewin scored twice as Leeds thumped Crystal Palace 4-1 at Elland Road to climb six points clear of the Premier League relegation zone.
Calvert-Lewin's double gave the Whites a 2-0 interval lead and captain Ethan Ampadu's first league goal for the club in the second half all-but sealed a deserved win for Daniel Farke's side, who gave their survival chances another big lift.
Palace substitute Justin Devenny converted a stoppage-time penalty, but it was too little too late for Oliver Glasner's side and the home side had the last word through Anton Stach's free-kick.
Free summer signing Calvert-Lewin has now scored in five straight Premier League games for the first time since October 2020 and notched a top-flight double for the first time since November of the same year.
The former Everton striker took his tally to six in his last five league matches and seven for the season as Leeds made it four games unbeaten.
Long-time league leaders Arsenal passed the first real test of their title credentials after briefly being overtaken by Manchester City but they were indebted to a moment of madness from Everton's Jake O'Brien.
Erling Haaland scored two goals and made another as Manchester City earned a comfortable 3-0 victory over West Ham.
Earlier, Joao Pedro denied Newcastle United victory as Chelsea came from behind to snatch a 2-2 draw at St James's Park.
