Evan Ferguson was a 61st-minute substitute as Roma ended Midtjylland's perfect record in the Europa League with a 2-1 home win on Thursday.
Last Sunday the Republic of Ireland striker ended his almost 13-month goal drought at club level when he scored in a 3-1 win at Cremonese that sent Roma top of Serie A.
He started on the bench this evening, coming on for Matias Soule just after the hour mark.
Midtjylland were the only side on maximum points after four matches but it was Roma who went in front at the Stadio Olimpico in the seventh minute.
Zeki Celik's floated pass into the box was met by Neil El Aynaoui's crisp volley to put the Serie A leaders in control and Roma looked to have wrapped up the win seven minutes from time with Stephan El Shaarawy's side-footed finish.
The visitors pulled one back with three minutes remaining, substitute Paulinho's goal making for a nervy ending for the home side. El Shaarawy rocked the crossbar with another effort as Roma held on and are now on nine points.
Midtjylland still lead the table but Aston Villa's win against Young Boys moves the Premier League side level on 12 points with the Danes and Lyon, who went top of the standings with a 6-0 rout of Maccabi Tel Aviv as Corentin Lorisso scored a hat-trick, with Maccabi's Sagiv Jehezkel sent off late on.
Martin O'Neill saw Celtic come from behind to beat Feyenoord 3-1 in Rotterdam in what is expected to be his final European game in charge.
Nottingham Forest picked up their second win in the competition as goals from Ryan Yates, Arnaud Kalimuendo and Nikola Milenkovic saw them ease to a 3-0 victory over Malmo.
However, Rangers' wait for a victory goes on as they were held to a 1-1 draw at home to 10-man Sporting Braga.
Freiburg missed the chance to go top after they were held to a goalless draw away to Viktoria Plzen, leaving them in fourth.
Real Betis moved up to fifth with a 2-1 win over Utrecht, and Robbie Keane's Ferencvaros are sixth, also on 11 points, following a 1-1 draw away to Fenerbahce.
Porto sit eighth, level on points with Sporting Braga, after cruising to a 3-0 win over rock-bottom Nice as Gabri Veiga scored a first-half brace.
Lille thrashed Dinamo Zagreb 4-0 while Ludogorets Razgrad held off a late fightback from Celta Vigo to pick up their second three-point haul with a 3-2 win.
Jamie Leweling's first-half brace helped Stuttgart to a 4-0 win away to Go Ahead Eagles, while Bologna overpowered RB Salzburg in the second half to secure a 4-1 win.
Genk hung on for a 2-1 win over Basel, Davide Calabria's 74th-minute strike gave Panathinaikos a 2-1 win over Sturm Graz, while a late equaliser from Emil Kornvig earned Brann a point from a 1-1 draw at PAOK.
Red Star Belgrade were reduced to 10 men early on with Franklin Tebo Uchenna dismissed, but Bruno Duarte's second-half strike earned a 1-0 win over FCSB.
