Borussia Dortmund are level on 10 points with Chelsea and Manchester City in the Champions League standings after Serhou Guirassy's double set them on course to thrash 10-man Villarreal 4-0.
Guinea international Guirassy struck either side of a red card for Juan Foyth before Karim Adeyemi and Daniel Svensson sealed victory.
Juventus needed a stoppage-time winner from substitute Jonathan David to defeat Norwegian club Bodo/Glimt 3-2 and claim a first victory of this season's competition.
Sondre Brunstad Fet's 87th-minute penalty looked to have earned the hosts a point after Juve pair Lois Openda and Weston McKennie overturned Ole Didrik Blomberg's first-half opener.
Scott McTominay spared the blushes of Rasmus Hojlund as Napoli celebrated victory on the fifth anniversary of Diego Maradona's death by beating Qarabag 2-0.
Scotland midfielder McTominay headed home a 65th-minute opener and then forced an own goal from Marko Jankovic after Manchester United loanee Hojlund had a penalty saved.
Pointless Ajax remain bottom of the table after goals from Samuel Dahl and Leandro Barreiro (abpve) secured Benfica a 2-0 success in Amsterdam and a first win of this season's tournament.
Belgian side Union Saint-Gilloise won 1-0 away to Galatasaray thanks to a second-half finish from Promise David, while Slavia Prague versus Athletic Bilbao ended goalless.
Pierre-Emerick Aubameyang's second-half brace earned Marseille a 2-1 comeback win over Newcastle, who led through Harvey Barnes.
Estevao scored an outstanding individual goal as Chelsea celebrated a stunning 3-0 win over 10-man Barcelona.
Manchester City paid the price for making wholesale changes as they slumped to a surprise 2-0 home loss to Bayer Leverkusen.
