Harry Kane scored the 400th goal of his club career as Bundesliga leaders Bayern Munich beat Borussia Dortmund 2-1 in Der Klassiker.
The England captain struck for the 22nd time in 14 appearances for club and country this season with a 22nd-minute header, but Michael Olise's 78th-minute contribution ultimately proved decisive after Julian Brandt reduced the deficit with six minutes remaining.
Alejandro Grimaldo's double and goals from Christian Kofane and Martin Terrier saw Bayer Leverkusen end up on the right end of a seven-goal thriller at Mainz.
The visitors led 2-0 and 4-2 at the Mewa Arena with Lee Jae-sung, Nadiem Amiri and Armindo Sieb at the death finding the back of the net to keep the hosts in it.
Tiago Tomas, Maximilian Mittelstadt and Angelo Stiller were on target as Stuttgart won 3-0 at Wolfsburg, while Christoph Baumgartner scored both goals in RB Leipzig's 2-1 home win over Hamburg.
Elsewhere, Heidenheim and Werder Bremen drew 2-2 and it finished 1-1 between Koln and Augsburg.
Substitute Ronald Araujo (above) spared Barcelona's blushes with a stoppage-time winner as they finally saw off Girona to climb to the top of the La Liga table.
Araujo struck in the third minute of added time to clinch a 2-1 victory at the Estadi Olimpic Lluis Companys after Axel Witsel had cancelled out Pedri's opener with a stunning overhead kick.
Atletico Madrid edged their way into the top four after substitute Thiago Almada 69th-minute strike sealed a 1-0 win over Osasuna.
Antony scored in stoppage time as Real Betis fought back from 2-0 down to draw 2-2 at Villarreal.
The former Manchester United midfielder struck in the fourth minute of added time after starting the comeback with his 66th-minute strike after goals from Tajon Buchanan and Alberto Moleiro had put the hosts in the driving seat.
Substitute Mateo Joseph scored twice as Real Mallorca won 3-1 at Sevilla, who took the lead through Ruben Vargas before Vedat Muriqi equalised and set the stage for his team-mate.
Ange-Yoan Bonny sent Inter Milan to the top of Serie A with the only goal in a 1-0 win at Roma, for whom Evan Ferguson came on in the 80th minute.
Bonny added the finishing touch to Nicolo Barella's sixth-minute through-ball to claim the points at the Stadio Olimpico.
Injury-hit champions Napoli lost 1-0 at Torino after a dramatic finish at the Stadio Olimpico Grande Torino.
Giovanni Simeone (above) had given the hosts a first-half lead, but they had to weather a storm after the break during which Noa Lang thought had had levelled in stoppage time after Matteo Politano's shot had come back off a post, only for his effort to be ruled out for offside after a VAR review.
Elsewhere, Sassuolo's trip to Lecce and lowly Pisa's home clash with Hellas Verona both finished goalless.
Mason Greenwood scored four times as Marseille routed 10-man Le Havre 6-2 to go top of Ligue 1.
The visitors led through Yassine Kechta's 24th-minute goal, but then had Gautier Lloris sent off for deliberate handball, Greenwood levelling from the spot before scoring three times in nine second-half minutes before Robinio Vaz and Amir Murillo struck either side of Abdoulaye Toure's effort.
Lyon's hopes of going top had earlier been dashed when they went down 3-2 at Nice.
Pavel Sulc scored twice for the visitors, but goals from Melvin Bard, Sofiane Diop and Hicham Boudaoui ensured it was the hosts who emerged victorious.
Sidiki Cherif snatched a 1-1 draw for Angers against Monaco with a late equaliser after fellow substitute Folarin Balogun had given the visitors a 72nd-minute lead.
