Áine O'Gorman and Karen Duggan will both hang up their boots after the final round of games in this season's SSE Airtricity Women's Premier Division on Saturday.
The pair played together for Peamount United, UCD Waves and the Republic of Ireland.
O'Gorman, who has been at Shamrock Rovers for the last three years, won 119 caps with the Girls in Green over an 18-year period, retiring from international duty after the 2023 World Cup in Australia and New Zealand.
The 36-year-old Wicklow native sits fourth in the all-time appearance list for the women’s national team.
She was one of two League of Ireland players in Vera Pauw's squad at the World Cup (along with her then clubmate at Shamrock Rovers Abbie Larkin).
Domestically O'Gorman enjoyed a trophy-laden spell at Peamount, lifting two League of Ireland titles (in 2019 and 2020) and two FAI Women’s Cups (2010 and 2020).
She scored over 200 league goals in the LOI across spells with Peamount, DLR Waves and three seasons with Shamrock Rovers.
Duggan, 34, was capped 35 times for Ireland. A natural leader, she started her career at Peamount but, along with with O'Gorman, followed boss Eileen Gleeson to UCD Waves (now known as DLR Waves) in 2014.
Duggan returned to the Peas in 2018 where she has been ever since. She won four league titles at Peamount and one FAI Cup.
O'Gorman's Shamrock Rovers face Shelbourne at Tallaght Stadium on Saturday, while Duggan will also be on home soil with the Peas as they welcome Bohemians to Greenogue.
Watch Portugal v Republic of Ireland in World Cup qualifying on Saturday from 7pm on RTÉ2 and RTÉ Player. Follow a live blog on rte.ie/sport and the RTÉ News app. Listen to live radio commentary on Saturday Sport on RTÉ Radio 1.
