Roma manager Gian Piero Gasperini explained fitness concerns were the reason Republic of Ireland international Evan Ferguson was an unused substitute as the club claimed their fifth win from six Serie A games with a 2-1 victory at struggling Fiorentina.
The 20-year-old, who made his seventh appearance since his loan move from Brighton against Lille midweek in the Europa League, dropped out of the starting team and failed to see any game time at Stadio Artemio Franchi, Gasperini explaining his absence after the match.
"Ferguson had an ankle issue on Thursday and still isn't fully fit," he told reporters.
Republic of Ireland manager Heimir Hallgrimsson will hope the Meath native, who scored in Ireland's shock defeat to Armenia last month, is fully recovered ahead of the upcoming World Cup qualifying double-header against Portugal (Saturday, 11 October) and Armenia three days later.
Moise Kean put the hosts ahead in Florence in the 14th minute but Roma responded impressively, Matias Soule equalising eight minutes later and Bryan Cristante netting what proved to be the winner with half an hour gone.
They sit at the top of the table just behind Napoli, whose game against Genoa followed the same pattern.
Patrick Vieira's Genoa are yet to claim a victory in the league this season but they took the lead in the 33rd minute through teenager Jeff Ekhator.
Patrick Vieira's Genoa are yet to claim a victory in the league this season but they took the lead in the 33rd minute through teenager Jeff Ekhator.
However, Frank Anguissa levelled the scores in the 57th minute and Rasmus Hojlund netted the fifth goal of his loan spell from Manchester United for a 75th-minute winner.
Bologna are sixth after hammering bottom side Pisa 4-0 while Udinese and Cagliari shared the points after a 1-1 draw.
Barcelona suffered a first La Liga defeat of the season as they were thumped 4-1 by 10-man Sevilla.
Victory would have taken the reigning champions back above Real Madrid at the top of the table but instead they completed a week that also included a Champions League loss to Paris St Germain in miserable fashion.
Former Barca playmaker Alexis Sanchez and Isaac Romero struck inside the opening 36 minutes for the hosts at the Ramon Sanchez-Pizjuan Stadium.
Marcus Rashford gave the visitors hope with a superb volley in first-half stoppage time but Robert Lewandowski spurned the chance to level from the penalty spot after a foul on the England forward.
And Sevilla made them pay as Jose Angel Carmona and Akor Adams scored in the closing stages either side of the sending-off of Peque.
High-flying Elche also suffered their first league loss of the season, going down 3-1 to Alaves, with all the goals scored in the final 15 minutes.
In Ligue 1, Lyon suffered their second defeat of the season, going down 2-1 at home to Toulouse.
Malick Fofana's 24th-minute goal looked like it would win it for OL but they were hit by two late sucker punches from Emersonn, with the Brazilian equalising in the 87th minute and then netting the winner six minutes into added time.
Strasbourg drew level with Lyon and Marseille thanks to a 5-0 thumping of lowly Angers, Joaquin Panichelli and Martial Godo both scoring twice.
Monaco missed the chance to also reach 15 points as they were held to a 2-2 draw at home to neighbours Nice.
An eventful encounter featured three penalties and a red card for Nice’s Ali Al-Abdi in the 34th minute.
Sofiane Diop had put the visitors 1-0 up before Al-Abdi’s exit and he doubled the advantage from the spot, only for Ansu Fati to pull one back with another penalty at the end of the first half.
Fati then drew the hosts level from another spot-kick in the 56th minute but they could not force a winner.
It was the same scoreline between Le Havre and Rennes while, in the Bundesliga, Stuttgart defeated Heidenheim 1-0 and Hamburg were 4-0 winners over Mainz.
