Republic of Ireland striker Evan Ferguson led the line for Roma as the Serie A side fell to a 1-0 home defeat to Lille in the Europa League.
The 20-year-old, who has yet to find the net since joining in the summer, was replaced in the 76th minute Artem Dovbyk, where an early goal from Hakon Arnar Haraldsson proved to be the only goal of the game.
In an unusual turn of events Roma had an opportunity to equalise in the 81st minute. The penalty had to be retaken three times for encroachment by Lille defenders. Miraculously Lille netminder Berke Ozer saved all three attempts to deny the Italian side a goal.
Nottingham Forest suffered defeat in their first European game at the City Ground in almost 30 years as the home fans turned on new boss Ange Postecoglou during a 3-2 loss to Midtjylland.
Postecoglou's winless run since he took over 22 days ago continued and the Forest fans vented their frustration, with chants of "sacked in the morning" aimed at the Australian alongside songs of support for former boss Nuno Espirito Santo.
The result meant Postecoglou became the first permanent Forest boss to be winless in his first six games in 100 years.
Emi Buendia and John McGinn struck second-half goals as Aston Villa beat Feyenoord 2-0 in Rotterdam to make it back-to-back Europa League wins.
Villa, who beat Bologna 1-0 in their tournament opener last week, held their nerve at De Kuip after coming under heavy first-half pressure, with Buendia and then McGinn firing killer blows for Unai Emery's side.
Back at the venue where they sealed the club’s greatest triumph by beating Bayern Munich to lift the European Cup in 1982, Villa notched their third win in a week to put their dismal start to the season behind them.
Celtic's city rivals Rangers slumped 2-1 away to Austrians Sturm Graz.
First-half defensive lapses resulted in a second Europa League defeat in eight days to keep the pressure on under-fire boss Russell Martin.
Elsewhere Lyon beat RB Salzburg 2-0, Porto were 2-1 winners against Red Star Belgrade and Celta Vigo trimuphed 3-1 at home to PAOK.
Stuttgart lost 2-0 in Basel, Fenerbahce sank Nice 2-1 and Malmo remain bottom of the pile after a 3-0 defeat at Viktoria Plzen.
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