On-loan Manchester United striker Rasmus Hojlund grabbed a brace as Napoli defeated Sporting Lisbon 2-1 to secure their first Champions League win of the season.
Former Manchester City midfielder Kevin de Bruyne set up both Hojlund goals, while Colombian forward Luis Suarez converted a penalty for the Portuguese visitors.
There was mixed fortune for English sides with Arsenal and Newcastle recording victories and Manchester City held in Monaco.
PSV Eindhoven drew 1-1 at Bayer Leverkusen and the points were also shared between Villarreal and Juventus in a 2-2 draw.
Georges Mikautadze put the LaLiga outfit ahead but Federico Gatti and Francisco Conceicao turned things around in dramatic fashion.
Renato Veiga, who was on loan at Juventus last season, rescued Villarreal in the dying seconds.
Borussia Dortmund beat Athletic Bilbao 4-1 while Qarabag became the first Azerbaijani side to record back-to-back Champions League wins with a 2-0 success over Copenhagen.
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