Ruben Amorim will attempt to balance the need to keep players fresh for Manchester United's crunch Europa League quarter-final against Lyon with the responsibility to try and beat Newcastle this weekend.
The Red Devils enter the weekend 13th in the Premier League and could tumble further before Sunday's match away to Eddie Howe's Carabao Cup winners.
United face a tough challenge at St James' Park four days before taking on Lyon, whose last-gasp goal on a nightmare night for Andre Onana saw them seal a 2-2 draw in the first leg of their make-or-break quarter-final.
The Europa League offers United's only route to silverware and continental qualification, with Amorim having to spin numerous plates as he seeks to beat Newcastle before the reverse fixture against the French side.
"There is a great responsibility," United's head coach said. "We don't have a team that is really big to do that and then we have players that I know cannot make 90 minutes in this moment still. We have to be really careful.
"So, we will try to address all these subjects in the game against Newcastle, but we have a great responsibility when we play any games.
"I will try to look at that, that is for sure but we have to face Newcastle with a team that we can be competitive and to win the game.
"Sometimes winning games is the best way of preparing for the next one. Of course, I am going to be careful with some players but, again, we need to be competitive.
"When you are playing for Manchester United you cannot go to the game thinking about the next one.
"So, we are going to face this one and then we have three days. We are going to prepare the game more in the way without a lot of running, a lot of training.
"It's just recovering and then we will be fine on Thursday with our fans, but we need to face Newcastle in a way that we can win the game."
Amorim expects to have the "same squad" at Newcastle that he took to Lyon, where Bruno Fernandes produced his latest man-of-the-match display.
Asked if it might come to a point where he takes the skipper out, Amorim said: "We will make this evaluation with all the staff, with all the data that we have.
"And then, because we know already the players, we will try to protect the ones that it will be hard to make a lot of games.
"But Bruno Fernandes is playing all the time and he is playing better all the time. Sometimes this kind of player has to play in every match, but we will address that in these days that we have to prepare."
Meanwhile United are looking into treatment of their fans in Lyon, with Football Supporters Europe criticising the police's "completely disproportionate" and "unacceptable" use of tear gas after the match.
Thursday’s first leg in France was attended by 2,800 away fans, who were required by local authorities to travel to a conference centre 13 miles away from the city centre to collect wristbands before boarding shuttle buses to the ground.
The significant expense and inconvenience of those demands were compounded by a malfunctioning public transport network and large queues at the pick-up point before being taken to the Groupama Stadium.
More issues were to follow after the 2-2 draw against Lyon, with tear gas deployed by police after fans attempted to use the toilet as they were held back for an hour before being ferried to the pick-up point.
It is understood United are looking at the issues and Ronan Evain, executive director of fan network FSE, has criticised the police response.
"It is completely unacceptable that the police would think it’s OK to stop people from going to the toilets, and then the reaction to it is completely disproportionate," he said.
"It is human nature that people will lose their temper if the police take away basic elements of basic human dignity like being allowed to go to the toilet.
"There, the police is responsible for creating this tension, for escalating it instead of taking the only logical decision in this situation, which is to permit people to go to the toilet, even if it’s only small groups.
"That they’re choosing to escalate this even further can’t be justified."
