Plymouth's reward for beating Liverpool in the FA Cup is a fifth round tie away to Manchester City.
The Pilgrims dumped the current Premier League leaders out of the competition with a 1-0 win on Sunday thanks to Ryan Hardie’s second-half penalty, and will now head to the Etihad Stadium for a last-16 tie against the seven-time Cup winners, who had to come from behind to beat Leyton Orient 2-1 on Saturday.
Holders Manchester United have been drawn at home to Fulham. United beat Leicester 2-1 in controversial circumstances, with Harry Maguire appearing to be in an offside position as he headed in Friday’s stoppage-time winner at Old Trafford.
There was no VAR in operation during the fourth-round ties over the weekend, but the technology will come into play from the next round onwards.
Having won 2-0 at Everton on Saturday Bournemouth will face more Premier League opposition with Wolves due at the Vitality Stadium.
Brighton, who came from behind to beat Chelsea 2-1, also have another tough assignment as they are away to Carabao Cup finalists Newcastle.
Cardiff, who needed penalties to get past Stoke, are away to Aston Villa – who hung on to knock out Tottenham 2-1 on Sunday.
Crystal Palace beat Doncaster 2-0 on Monday evening and as a result, will be at home to Millwall, while the winners of Tuesday’s tie between Exeter and Nottingham Forest will be at home to Ipswich.
There will also be an all-Championship tie in the north-west with Preston due to host Burnley.
Games will be played over the first weekend in March.
Meanwhile, in Scotland Queen's Park have landed a quarter-final trip to Aberdeen as their reward for Sunday’s stunning Scottish Cup triumph away to Rangers.
The Championship outfit will head to Pittodrie to face another Premiership opponent after their shock 1-0 win at Ibrox.
Elsewhere, holders Celtic will host 2016 winners Hibernian, who are unbeaten in their last 11 matches.
In-form city rivals Hearts, who progressed to the last eight with a penalty shootout victory away to St Mirren on Monday, will host top-flight rivals Dundee, whom they thrashed 6-0 earlier this month. The Dens Park side have not won the competition since 1910.
Championship promotion chasers Livingston will host 2021 winners and Premiership strugglers St Johnstone.
The ties will take place on the weekend of 8-9 March.
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