Belgium striker Romelu Lukaku has been ruled out of Saturday's friendly with the Republic of Ireland in the Aviva Stadium.
The Roma striker has a groin issue so will sit out the game with a view to being available to feature against England.
In a short statement the Belgian FA said: "Romelu Lukaku is not fit for the game against the Republic of Ireland due to a slightly overloaded groin.
"He left the camp but will travel with the team on Friday to the Republic of Ireland and England."
He joins Kevin De Bruyne on the sidelines for the game who was ruled out last week.
Arsenal striker Leandro Trossard is one of a number of attacking options for Belgium still remaining.
Liam Scales and Troy Parrott are both out of the Republic of Ireland's upcoming friendlies.
Meanwhile, Real Madrid goalkeeper Thibaut Courtois will be out of action for several weeks after incurring a meniscus tear in his right knee during training on Tuesday, the La Liga club has said.
The 31-year-old Belgian international, who had not been included in the national team squad for March, had been expected to return to Real's squad after an ACL tear in his left knee last August. He underwent an MRI scan later on Tuesday that confirmed the damage to his right knee.
"Following tests carried out today, our player Thibaut Courtois has been diagnosed with a ruptured internal meniscus in his right knee," the club said in a statement.
Goalkeepers: Arnaud Bodart, Koen Casteels, Thomas Kaminski, Matz Sels
Defenders: Timothy Castagne, Koni De Winter, Zeno Debast, Wout Faes, Thomas Meunier, Arthur Theate, Jan Vertonghen
Midfielders: Olivier Deman, Jeremy Doku, Dodi Lukebakio, Orel Mangala, Amadou Onana, Youri Tielemans, Arthur Vermeeren, Aster Vranckx
Forwards: Johan Bakayoko, Michy Batshuayi, Charles De Ketelaere, Loïs Openda, Leandro Trossard
Follow a live blog on Republic of Ireland v Belgium this Saturday from 5pm on rte.ie/sport and the RTÉ News app and listen to commentary on Saturday Sport on RTÉ Radio 1
Additional reporting: Reuters
