Republic of Ireland international Chiedozie Ogbene was on the scoresheet as he helped Luton to come from behind and see off League One Bolton at the second attempt with a 2-1 win in their FA Cup third round replay at the Toughsheet Community Stadium.
Having held their Premier League opponents goalless nine days ago, Bolton stunned the Hatters when Dion Charles put them ahead 11 minutes in.
But Tahith Chong swiftly equalised before Ogbene's second-half goal set up a tie against the winners of Wednesday's replay between Everton and Crystal Palace.
Ogbene's winner arrived in the 57th minute when striker Carlton Morris fired in a precise low cross from the left and the Cork native slammed home his first FA Cup goal.
Nathan Collins scored for Brentford against former club Wolves at Molineux but the Bees fell to a 3-2 extra-time defeat to Gary O'Neill's side who set up a fourth-round derby showdown with near neighbours West Brom.
Wolves hit back through Nelson Semedo and Nathan Fraser in normal time after Ireland defender Collins and Neal Maupay twice gave the visitors the lead.
But Matheus Cunha's extra-time spot kick booked a Black Country derby at the Hawthorns, the first in three years, on 28 January.
The Bees will be left with a blank weekend but will at least have Ivan Toney available having missed him during a barren winter, during which they have won once since the start of November.
The striker completes his eight-month ban for betting breaches on Wednesday.
Bristol City produced an upset as 10-man West Ham were beaten 1-0 in their replay at Ashton Gate.
Tommy Conway's equaliser at the London Stadium nine days earlier had set up this return tie and the 21-year-old striker was the Robins' hero again as his early goal proved the difference.
West Ham, sixth in the Premier League, suffered further misery as Said Benrahma was sent off after 51 minutes for reacting to a strong challenge from Joe Williams.
Bristol City, 14th in the Sky Bet Championship, will again meet top-flight opposition in the fourth round should Nottingham Forest successfully negotiate their replay at Blackpool on Wednesday.
A stoppage-time goal from Koji Miyoshi earned Birmingham a 2-1 win over Hull to book a fourth-round trip to Leicester.
The result earned Tony Mowbray his first victory since taking over as manager at St Andrew's following the sacking of Wayne Rooney.
Birmingham had to come back from a goal down to win the tie after Jason Lokilo's first goal for Hull put them ahead after 12 minutes.
Mowbray made five substitutions just past the hour-mark and it was a move that changed the game.
Two of those substitutes scored, with Jay Stansfield equalising three minutes after coming on.
Newport set up a fairytale tie with Manchester United with a 3-1 win at non-league Eastleigh.
Goals from James Clarke and Will Evans sent the Welsh side through after Paul McCallum briefly levelled for the fifth-tier Spitfires following Aaron Wildig's early opener.
The Exiles will host 12-time cup winners United at Rodney Parade on 28 January.
