Kylian Mbappe inspired 10-man Paris St Germain to a 2-0 victory over Le Havre to send them four points clear of Nice at the top of Ligue 1.
PSG found themselves down to 10 men after just 10 minutes when goalkeeper Gianluigi Donnarumma was sent off for a high challenge on Josue Casimir.
The visitors went in front in the 23rd minute through Mbappe and while the hosts did their best to find an equaliser, Vitinha scored against the run of play in the 89th minute to seal three points.
Goalkeeper Lucas Chevalier saved two penalties as Lille claimed a 2-0 win at home to Metz.
The 22-year-old denied Simon Elisor before two goals in first-half stoppage time from Yusuf Yazici and Jonathan David put Lille in front.
More heroics from Chevalier 10 minutes into the second half to keep out Lamine Camara's penalty helped preserve victory for the home side.
Monaco kept pace with PSG with a 2-0 win over 10-man Montpellier, who saw Boubakar Kouyate sent off in the second half, while Brest beat Clermont 3-0 and Toulouse played out a 1-1 draw with Lorient.
In La Liga, Joao Felix undid his parent club as a first-half finish from the Portugal international earned Barcelona a 1-0 victory over Atletico Madrid at the Lluis Companys Olympic Stadium.
Felix lifted the ball over goalkeeper Jan Oblak in deft fashion in the 28th minute as Xavi's men replaced Atletico in third in the LaLiga table, with a four-point gap to leaders Real Madrid and second-placed Girona
Sevilla were held 1-1 at home by Villarreal, Hector Bellerin was shown a red card in the 27th minute of Real Betis' goalless draw at Almeria, and Mallorca and Alaves also drew a blank.
Rasmus Kristensen scored the winner for Roma as they came from behind to beat Sassuolo 2-1 in Serie A.
Matheus Henrique fired in a first-half opener for Sassuolo, but it all came undone after the break when Daniel Boloca was dismissed and Paulo Dybala scored from the spot, before Kristensen fired home a second.
A Lucas Beltran spot-kick and further goals from Riccardo Sottil and Giacomo Bonaventura earned Fiorentina a 3-0 victory over Salernitana, while Udinese - who brought Festy Ebosele off the bench in the second half - drew 3-3 with Verona.
Sixth-placed Bologna looked poised for victory at Lecce but had to settle for a point after Roberto Piccoli's penalty in the 10th minute of second-half stoppage time cancelled out Charalampos Lykogiannis' 68th-minute opener.
In the Bundesliga, Borussia Dortmund were on course to leapfrog fourth-placed Leipzig with a vital victory at leaders Bayer Leverkusen after Julian Ryerson fired the visitors ahead after five minutes.
But Victor Boniface salvaged a point when he levelled late in the second half.
