Cork's Jake O’Brien found the net twice for Lyon but it wasn’t enough as they lost 3-2 to 10-man Lens in Ligue 1.
The defender, who signed for the French side in August, put the basement club into the lead in the 14th minute before Wesley Saïd and Przemyslaw Frankowski, from the penalty spot, put Lens ahead as they tried to recover from their Champions League mauling by Arsenal.
O’Brien drew Lyon level again in the 72nd minute but Lyon, who lost Florian Sotoca to a red card in the final moments, found a winner as Frankowski scored his second.
Elsewehere, Florent Mollet's goal was the difference for Nantes to beat Nice 1-0.
Real Madrid returned to the top of the La Liga table with a 2-0 win against struggling Granada.
Rodrygo continued his impressive scoring streak with his seventh goal in his last five Real appearances to seal victory at the Bernabeu following Brahim Diaz's first-half opener.
It means Real are now tied on 38 points with Girona at the top after Cristhian Stuani's late brace saw the latter beat Valencia 2-1.
Hugo Duro gave Valencia the lead and they looked set to see out the win, but Stuani levelled in the 82nd minute before completing the comeback by scoring the winner six minutes later.
Osasuna and Real Sociedad settled for a 1-1 draw, while Athletic Bilbao moved into fifth in the table after beating Rayo Vallecano 4-0.
Gorka Guruzeta put them ahead in the first half and they extended their lead after half-time when Alfonso Espino turned the ball into his own net before brothers Inaki Williams and Nico Williams struck in quick succession.
In Serie A, Luka Jovic scored his first AC Milan goal as they beat Frosinone 3-1 at San Siro.
Christian Pulisic scored a superb individual effort and Fikayo Tomori wrapped up the win before Marco Brescianini scored a late consolation for the visitors.
Pedro handed Lazio a 1-0 win against Cagliari, who were reduced to 10 men in the 27th minute when Antoine Makoumbou was sent off.
Matteo Cancellieri earned a point for Empoli as they drew 1-1 with Genoa, who had led through Ruslan Malinovskyi.
Stuttgart closed the gap at the top of the Bundesliga with a 2-0 win against Werder Bremen.
Deniz Undav and Sehrou Guirassy were both on target for Stuttgart, who remain third in the table but are now two points away from second-placed Bayern Munich whose game against Union Berlin was cancelled due to snow.
RB Leipzig sit just behind Stuttgart in fourth following a 2-1 win over Heidenheim, going ahead through Lois Openda and Yussuf Poulsen before Benedikt Gimber pulled one back.
Nathan Ngoumou scored the winner as Borussia Monchengladbach beat Hoffenheim 2-1, while Bochum earned their first home league win of the season with a 3-1 victory against Wolfsburg.
