Brighton and Hove Albion completed a Europa League double over Ajax as Roberto De Zerbi's men triumphed 2-0 at Johan Cruyff Arena.
In a repeat of the scoreline when the sides had met at the Amex Stadium two weeks earlier, Ansu Fati - adding to his effort in that initial encounter - opened the scoring early on before Simon Adingra doubled the lead eight minutes into the second half.
Republic of Ireland striker Evan Ferguson replaced Fati with 65 minutes on the clock.
Liverpool's 100% record in Group E came to an end as they were beaten 3-2 at Toulouse, being denied a late equaliser via VAR. Jurgen Klopp's side remain top of their pool, with Toulouse now two points behind in second.
Lucas Paqueta got West Ham's European campaign back on track with the winner in a 1-0 victory over Olympiacos.
The Brazil midfielder crashed in a second-half volley to keep the Hammers on top of Group A and to the brink of qualifying for the knockout stages.
Rangers moved clear into second place in Group C with what turned out to be a nervy 2-1 win over Sparta Prague at Ibrox.
The two sides fought out a goalless draw in the Czech Republic last month but it took only 11 minutes for Brazilian striker Danilo to get the breakthrough before midfielder Todd Cantwell added a second in the 20th minute.
The visitors smartened up after the break however, with substitute Lukas Haraslin reducing the deficit in the 77th minute and although Danilo soon had the ball in the net again it was ruled out after VAR check for a foul and in the end the home players and fans were glad to hear the final whistle.
Philippe Clement has now gone six games unbeaten since taking over as Light Blues boss and incremental improvement is clear but they were holding on at the end
Roma lost 2-0 at Slavia Prague courtesy of second-half goals from Vaclav Jurecka and Lukas Masopust, a result that sees the Czech side usurp their opponents at the top of Group G on goal difference.
In Group F, table-toppers Rennes beat Panathinaikos 3-1 at home despite having Jeanuel Belocian sent off in the first half.
Villarreal replaced the Greeks in second after coming from behind to win 2-1 at Maccabi Haifa thanks to late goals from Alex Baena and former Crystal Palace forward Alexander Sorloth.
Bayer Leverkusen are yet to drop a point in Group H following their 1-0 win at Qarabag.
In the Europa Conference League Jamie McGrath's 30-yard free-kick earned Aberdeen a point against PAOK in Greece but it was not enough to keep the Dons in the competition beyond Christmas.
McGrath - named in Stephen Kenny's Republic of Ireland squad today - struck soon after PAOK took the lead midway through the second half after fighting back from an early opener from Luis 'Duk' Lopes.
The 2-2 draw in Thessaloniki earned Aberdeen their second point in Group G but PAOK moved to 10 points, while Eintracht Frankfurt's win over HJK Helsinki moved the Germans on to nine points after four games.
The damage in the group had been done when PAOK fought back from a two-goal deficit to win at Pittodrie deep in stoppage-time two weeks earlier.
Ollie Watkins came to Aston Villa's rescue as Unai Emery's side hit back to beat AZ Alkmaar.
The striker celebrated his England call-up to nod in with nine minutes left for a 2-1 win and put Villa on the brink of the Europa Conference League knockout stages.
Diego Carlos' controversial goal - heading in a corner which should have never been given - quickly cancelled out Vangelis Pavlidis' opener.
Victory left Villa joint-top of Group E, behind Legia Warsaw on their head-to-head record, knowing a point from their final two games would guarantee progress.
