Manchester City will begin their bid for a record fourth consecutive Premier League title away to Vincent Kompany's Burnley.
The Treble winners will visit Turf Moor to face their former captain's newly-promoted side on the evening of Friday, 11 August to raise the curtain on the 2023-24 campaign.
It will be the second time Kompany - who won the title on four occasions as City skipper - will have faced his old side as a manager, with City running out 6-0 winners at the Etihad in March's FA Cup quarter-final.
Jurgen Klopp's Liverpool have been handed a tricky start to the season with a trip to Mauricio Pochettino's Chelsea on Sunday 13 August with both sides looking to bounce back after disappointing campaigns.
Manchester United begin their campaign against Wolves at Old Trafford on Monday, 14 August.
The first Merseyside derby of the campaign sees Everton go to Anfield on 21 October, while Pochettino will take his new side to face his old one when Chelsea visit Tottenham on 4 November.
The first north London derby of the campaign sees Spurs visit Arsenal on 23 September (with the return on April 27) while Man City travel to the Emirates on 7 October for a meeting of last season's top two.
October 28 at Old Trafford will bring the first Manchester derby since City matched United's Treble-winning feat of 1999 (United go to the Etihad on 2 March), with the champions hosting Klopp's Liverpool on 25 November.
Premier League debutants Luton will play their first top-flight fixture since 1992 away to Roberto De Zerbi's Brighton on Saturday, 12 August, having to wait until the following weekend for their first home game when Kenilworth Road will become the smallest ground to host a fixture in the competition for the visit of Burnley.
The other promoted side Sheffield United kick off their season with a home game against Crystal Palace.
📣 #PLFixtures for the 2023/24 season have arrived!
— Premier League (@premierleague) June 15, 2023
Arsenal, following an anticlimactic conclusion to last season's title challenge, open at home to Nottingham Forest in Saturday's lunchtime game, with fellow Champions League qualifiers Newcastle hosting Aston Villa that evening and Manchester United beginning against Wolves at Old Trafford on Monday, 14 August.
Mikel Arteta is unlikely to be impressed with Arsenal's schedule, with the club's first two Champions League fixtures in six years coming immediately ahead of games against Tottenham and City.
Ange Postecoglou's first game in charge of Tottenham will be away to Brentford at 2pm on Sunday, Bournemouth open at home to Europa Conference League winners West Ham, and Everton, looking to avoid a third straight relegation scrap, begin at home to Fulham.
Luton have been handed a seemingly kind start to life in the Premier League, their only meeting with any of the 'big six' in their first seven games coming away at Chelsea on August 26.
The final weekend sees all three promoted sides play at home, with Burnley welcoming Forest, Sheffield United hosting Spurs and Luton playing Fulham.
