Paris St Germain crashed out of the Coupe de France after losing 2-1 at Marseille.
Alexis Sanchez's penalty and Ruslan Malinovskyi’s winner sent Marseille through.
Sergio Ramos levelled in first-half stoppage time but the Ligue 1 leaders must wait to add to their 14 titles after exiting in the last 16.
Holders Nantes edged past Angers 4-2 on penalties after a 1-1 draw while Lyon also beat Lille 4-2 in a shootout after finishing 2-2.
Rodez beat Auxerre 3-2, Toulouse overcame Reims 3-1 and Annecy knocked out Paris FC 6-5 on penalties.
Grenoble advanced following a 1-0 win at Vierzon.
Elsewhere, Borussia Dortmund reached the last eight of the German Cup with a 2-1 win at Bochum.
Emre Can and Marco Reus scored for the visitors either side of Kevin Stoger’s penalty.
Nuremberg beat Fortuna Dusseldorf 5-3 on penalties following a 1-1 draw.
