Women's Super League champions Chelsea will take on Paris St Germain and Real Madrid in group matches in the Champions League.
Chelsea were among the top four seeds in Monday's draw but find themselves in a group containing two of the biggest names in European football as well as Albanian minnows Vllaznia.
PSG reached the semi-finals of the tournament last year and Real Madrid the quarters, where they lost to Barcelona in front of more than 90,000 people.
Chelsea, runners-up to Barcelona in 2021, will look to right the wrongs from last season, when a 4-0 defeat by Wolfsburg condemned them to a hugely disappointing group stage exit.
Arsenal, after narrowly beating Ajax over two legs, were also handed a tricky-looking draw.
They must take on defending champions Lyon, who defeated Barcelona in the final last season, and Juventus in Group C as well as Swiss side Zurich.
The group stage games will be played between 19 October and 22 December.